Open Access

Innate immune evasion strategies against Cryptococcal meningitis caused by Cryptococcus neoformans (Review)

  • Authors:
    • Cheng‑Liang Yang
    • Jun Wang
    • Li‑Li Zou
  • View Affiliations

  • Published online on: September 29, 2017     https://doi.org/10.3892/etm.2017.5220
  • Pages:5243-5250
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

As an infectious fungus that affects the respiratory tract, Cryptococcus neoformans (C. neoformans) commonly causes asymptomatic pulmonary infection. C. neoformans may target the brain instead of the lungs and cross the blood‑brain barrier (BBB) in the early phase of infection; however, this is dependent on successful evasion of the host innate immune system. During the initial stage of fungal infection, a complex network of innate immune factors are activated. C. neoformans utilizes a number of strategies to overcome the anti‑fungal mechanisms of the host innate immune system and cross the BBB. In the present review, the defensive mechanisms of C. neoformans against the innate immune system and its ability to cross the BBB were discussed, with an emphasis on recent insights into the activities of anti‑phagocytotic and anti‑oxidative factors in C. neoformans.

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Journal Cover

December 2017
Volume 14 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
(total number of cites)

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APA
Yang, C., Wang, J., & Zou, L. (2017). Innate immune evasion strategies against Cryptococcal meningitis caused by Cryptococcus neoformans (Review). Experimental and Therapeutic Medicine, 14, 5243-5250. https://doi.org/10.3892/etm.2017.5220
MLA
Yang, C., Wang, J., Zou, L."Innate immune evasion strategies against Cryptococcal meningitis caused by Cryptococcus neoformans (Review)". Experimental and Therapeutic Medicine 14.6 (2017): 5243-5250.
Chicago
Yang, C., Wang, J., Zou, L."Innate immune evasion strategies against Cryptococcal meningitis caused by Cryptococcus neoformans (Review)". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5243-5250. https://doi.org/10.3892/etm.2017.5220