Open Access

Curcumin suppresses AGEs induced apoptosis in tubular epithelial cells via protective autophagy

  • Authors:
    • Ying Wei
    • Jiaqi Gao
    • Lingling Qin
    • Yunling Xu
    • Haoxia Shi
    • Lingxia Qu
    • Yongqiao Liu
    • Tunhai Xu
    • Tonghua Liu
  • View Affiliations

  • Published online on: October 16, 2017     https://doi.org/10.3892/etm.2017.5314
  • Pages:6052-6058
  • Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Renal tubular cell apoptosis and tubular dysfunction is an important process underlying diabetic nephropathy (DN). Understanding the mechanisms underlying renal tubular epithelial cell survival is important for the prevention of kidney damage associated with glucotoxicity. Curcumin has been demonstrated to possess potent anti‑apoptotic properties. However, the roles of curcumin in renal epithelial cells are yet to be defined. The present study investigated advanced glycation or glycoxidation end‑product (AGE)‑induced toxicity in renal tubular epithelial cells via several complementary assays, including cell viability, cell apoptosis and cell autophagy in the NRK‑52E rat kidney tubular epithelial cell line. The extent of apoptosis was significantly increased in the NRK‑52E cells following treatment with AGEs. The results also indicated that curcumin reversed this effect by promoting autophagy through the phosphoinositide 3‑kinase/AKT serine/threonine kinase signaling pathway. These conclusions suggested that curcumin exerts a renoprotective effect in the presence of AGEs, at least in part by activating autophagy in NRK‑52E cells. Collectively, these findings indicate that curcumin not only exerts renoprotective effects, however may also act as a novel therapeutic strategy for the treatment of diabetic nephropathy.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Wei, Y., Gao, J., Qin, L., Xu, Y., Shi, H., Qu, L. ... Liu, T. (2017). Curcumin suppresses AGEs induced apoptosis in tubular epithelial cells via protective autophagy. Experimental and Therapeutic Medicine, 14, 6052-6058. https://doi.org/10.3892/etm.2017.5314
MLA
Wei, Y., Gao, J., Qin, L., Xu, Y., Shi, H., Qu, L., Liu, Y., Xu, T., Liu, T."Curcumin suppresses AGEs induced apoptosis in tubular epithelial cells via protective autophagy". Experimental and Therapeutic Medicine 14.6 (2017): 6052-6058.
Chicago
Wei, Y., Gao, J., Qin, L., Xu, Y., Shi, H., Qu, L., Liu, Y., Xu, T., Liu, T."Curcumin suppresses AGEs induced apoptosis in tubular epithelial cells via protective autophagy". Experimental and Therapeutic Medicine 14, no. 6 (2017): 6052-6058. https://doi.org/10.3892/etm.2017.5314