Open Access

Morphological and molecular comparisons between tibialis anterior muscle and levator veli palatini muscle: A preliminary study on their augmentation potential

  • Authors:
    • Xu Cheng
    • Lei Song
    • Min Lan
    • Bing Shi
    • Jingtao Li
  • View Affiliations

  • Published online on: October 30, 2017     https://doi.org/10.3892/etm.2017.5391
  • Pages:247-253
  • Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Tibialis anterior (TA) muscle and other somite‑derived limb muscles remain the prototype in skeletal muscle study. The majority of head muscles, however, develop from branchial arches and maintain a number of heterogeneities in comparison with their limb counterparts. Levator veli palatini (LVP) muscle is a deep‑located head muscle responsible for breathing, swallowing and speech, and is central to cleft palate surgery, yet lacks morphological and molecular investigation. In the present study, multiscale in vivo analyses were performed to compare TA and LVP muscle in terms of their myofiber composition, in‑situ stem cell population and augmentation potential. TA muscle was identified to be primarily composed of type 2B myofibers while LVP muscle primarily consisted of type 2A and 2X myofibers. In addition, LVP muscle maintained a higher percentage of centrally‑nucleated myofibers and a greater population of satellite cells. Notably, TA and LVP muscle responded to exogenous Wnt7a stimulus in different ways. Three weeks after Wnt7a administration, TA muscle exhibited an increase in myofiber number and a decrease in myofiber size, while LVP muscle demonstrated no significant changes in myofiber number or myofiber size. These results suggested that LVP muscle exhibits obvious differences in comparison with TA muscle. Therefore, knowledge acquired from TA muscle studies requires further testing before being applied to LVP muscle.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Cheng, X., Song, L., Lan, M., Shi, B., & Li, J. (2018). Morphological and molecular comparisons between tibialis anterior muscle and levator veli palatini muscle: A preliminary study on their augmentation potential. Experimental and Therapeutic Medicine, 15, 247-253. https://doi.org/10.3892/etm.2017.5391
MLA
Cheng, X., Song, L., Lan, M., Shi, B., Li, J."Morphological and molecular comparisons between tibialis anterior muscle and levator veli palatini muscle: A preliminary study on their augmentation potential". Experimental and Therapeutic Medicine 15.1 (2018): 247-253.
Chicago
Cheng, X., Song, L., Lan, M., Shi, B., Li, J."Morphological and molecular comparisons between tibialis anterior muscle and levator veli palatini muscle: A preliminary study on their augmentation potential". Experimental and Therapeutic Medicine 15, no. 1 (2018): 247-253. https://doi.org/10.3892/etm.2017.5391