Open Access

Implications of dietary ω‑3 and ω‑6 polyunsaturated fatty acids in breast cancer (Review)

  • Authors:
    • Oana Zanoaga
    • Ancuta Jurj
    • Lajos Raduly
    • Roxana Cojocneanu‑Petric
    • Enrique Fuentes‑Mattei
    • Oscar Wu
    • Cornelia Braicu
    • Claudia Diana Gherman
    • Ioana Berindan‑Neagoe
  • View Affiliations

  • Published online on: November 16, 2017     https://doi.org/10.3892/etm.2017.5515
  • Pages: 1167-1176
  • Copyright: © Zanoaga et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Breast cancer represents one of the most common forms of cancer in women worldwide, with an increase in the number of newly diagnosed patients in the last decade. The role of fatty acids, particularly of a diet rich in ω‑3 and ω‑6 polyunsaturated fatty acids (PUFAs), in breast cancer development is not fully understood and remains controversial due to their complex mechanism of action. However, a large number of animal models and cell culture studies have demonstrated that high levels of ω‑3 PUFAs have an inhibitory role in the development and progression of breast cancer, compared to ω‑6 PUFAs. The present review focused on recent studies regarding the correlation between dietary PUFAs and breast cancer development, and aimed to emphasize the main molecular mechanisms involved in the modification of cell membrane structure and function, modulation of signal transduction pathways, gene expression regulation, and antiangiogenic and antimetastatic effects. Furthermore, the anticancer role of ω‑3 PUFAs through the modulation of microRNA expression levels was also reviewed.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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APA
Zanoaga, O., Jurj, A., Raduly, L., Cojocneanu‑Petric, R., Fuentes‑Mattei, E., Wu, O. ... Berindan‑Neagoe, I. (2018). Implications of dietary ω‑3 and ω‑6 polyunsaturated fatty acids in breast cancer (Review). Experimental and Therapeutic Medicine, 15, 1167-1176. https://doi.org/10.3892/etm.2017.5515
MLA
Zanoaga, O., Jurj, A., Raduly, L., Cojocneanu‑Petric, R., Fuentes‑Mattei, E., Wu, O., Braicu, C., Gherman, C. D., Berindan‑Neagoe, I."Implications of dietary ω‑3 and ω‑6 polyunsaturated fatty acids in breast cancer (Review)". Experimental and Therapeutic Medicine 15.2 (2018): 1167-1176.
Chicago
Zanoaga, O., Jurj, A., Raduly, L., Cojocneanu‑Petric, R., Fuentes‑Mattei, E., Wu, O., Braicu, C., Gherman, C. D., Berindan‑Neagoe, I."Implications of dietary ω‑3 and ω‑6 polyunsaturated fatty acids in breast cancer (Review)". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1167-1176. https://doi.org/10.3892/etm.2017.5515