Allicin activates autophagic cell death to alleviate the malignant development of thyroid cancer

  • Authors:
    • Yangfeng Xiang
    • Jianqiang Zhao
    • Ming Zhao
    • Kejing Wang
  • View Affiliations

  • Published online on: February 1, 2018     https://doi.org/10.3892/etm.2018.5828
  • Pages: 3537-3543
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Abstract

Allicin has been reported to inhibit cancer cell proliferation, induce cell apoptosis and enhance the accumulation of reactive oxygen species. However, it has remained elusive whether allicin improves multidrug resistance in thyroid cancer cells through modulating autophagy. The present study demonstrated that combined use of allicin and cisplatin or carboplatin resulted in an enhanced growth inhibitory effect on SW1736 and HTh‑7 cells. Furthermore, treatment with allicin significantly increased SW1736 and HTh‑7 cell autophagy. Of note, allicin‑induced cell death was largely abolished by 3‑methyladenine or chloroquine treatment, suggesting that allicin‑induced A549 cell death was dependent on autophagy. Western blot analysis demonstrated that allicin treatment inhibited the activation of Akt, mammalian target of rapamycin and S6. Furthermore, it was demonstrated that combined use of allicin and rapamycin induced more cell death compared with that induced by allicin or rapamycin alone. In conclusion, allicin may serve as an adjunctive therapy for thyroid cancer, as it induces autophagy‑dependent cell death even when cancer cells have developed apoptosis resistance.
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April-2018
Volume 15 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Xiang Y, Zhao J, Zhao M and Wang K: Allicin activates autophagic cell death to alleviate the malignant development of thyroid cancer. Exp Ther Med 15: 3537-3543, 2018
APA
Xiang, Y., Zhao, J., Zhao, M., & Wang, K. (2018). Allicin activates autophagic cell death to alleviate the malignant development of thyroid cancer. Experimental and Therapeutic Medicine, 15, 3537-3543. https://doi.org/10.3892/etm.2018.5828
MLA
Xiang, Y., Zhao, J., Zhao, M., Wang, K."Allicin activates autophagic cell death to alleviate the malignant development of thyroid cancer". Experimental and Therapeutic Medicine 15.4 (2018): 3537-3543.
Chicago
Xiang, Y., Zhao, J., Zhao, M., Wang, K."Allicin activates autophagic cell death to alleviate the malignant development of thyroid cancer". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3537-3543. https://doi.org/10.3892/etm.2018.5828