Inhibitory effects of methamphetamine on mast cell activation and cytokine/chemokine production stimulated by lipopolysaccharide in C57BL/6J mice

Xue,Li; Geng,Yan; Li,Ming; Jin,Yao‑Feng; Ren,Hui‑Xun; Li,Xia; Wu,Feng; Wang,Biao; Cheng,Wei‑Ying; Chen,Teng; Chen,Yan‑Jiong

doi:10.3892/etm.2018.5837

Inhibitory effects of methamphetamine on mast cell activation and cytokine/chemokine production stimulated by lipopolysaccharide in C57BL/6J mice

Authors:
- Li Xue
- Yan Geng
- Ming Li
- Yao‑Feng Jin
- Hui‑Xun Ren
- Xia Li
- Feng Wu
- Biao Wang
- Wei‑Ying Cheng
- Teng Chen
- Yan‑Jiong Chen
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Affiliations: Department of Immunology and Pathogenic Biology, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an, Shaanxi 710061, P.R. China, Department of Laboratory, The Second Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Cardiovascular Surgery, The First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Pathology, The Second Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China, VIP Internal Medicine Department, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, P.R. China, Graduate Teaching and Experiment Centre, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an, Shaanxi 710061, P.R. China, Forensic Medicine College of Xi'an Jiaotong University, Key Laboratory of The Health Ministry for Forensic Medicine, Key Laboratory of The Ministry of Education for Environment and Genes Related to Diseases, Xi'an, Shaanxi 710061, P.R. China
Published online on: February 5, 2018 https://doi.org/10.3892/etm.2018.5837
Pages: 3544-3550

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Abstract

Previous studies have demonstrated that methamphetamine (MA) influences host immunity; however, the effect of MA on lipopolysaccharide (LPS)-induced immune responses remains unknown. Mast cells (MCs) are considered to serve an important role in the innate and acquired immune response, but it remains unknown whether MA modulates MC activation and LPS‑stimulated cytokine production. The present study aimed to investigate the effect of MA on LPS‑induced MC activation and the production of MC‑derived cytokines in mice. Markers for MC activation, including cluster of differentiation 117 and the type I high affinity immunoglobulin E receptor, were assessed in mouse intestines. Levels of MC‑derived cytokines in the lungs and thymus were also examined. The results demonstrated that cytokines were produced in the bone marrow-derived mast cells (BMMCs) of mice. The present study demonstrated that MA suppressed the LPS‑mediated MC activation in mouse intestines. MA also altered the release of MC cytokines in the lung and thymus following LPS stimulation. In addition, LPS‑stimulated cytokines were decreased in the BMMCs of mice following treatment with MA. The present study demonstrated that MA may regulate LPS‑stimulated MC activation and cytokine production.

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