Open Access

Effects of compound Danshen injection combined with magnesium sulfate on serum MPO and hs-CRP in patients with severe preeclampsia

  • Authors:
    • Kun Yang
    • Gaoxia Dong
    • Ying Tian
    • Jian Li
  • View Affiliations

  • Published online on: May 17, 2018     https://doi.org/10.3892/etm.2018.6173
  • Pages: 167-170
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Effects of compound Danshen injection combined with magnesium sulfate on serum myeloperoxidase (MPO) and hypersensitive C-reactive protein (hs-CRP) in patients with severe preeclampsia (PE) were investigated. Five hundred patients with severe PE were randomly divided into early‑onset observation, early-onset control, late-onset observation and late-onset control groups. Control group was treated with magnesium sulfate, while patients in observation group were treated with magnesium sulfate combined with compound Danshen injection. Serum levels of MPO and hs-CRP were measured by enzyme-linked immunosorbent assay (ELISA) and turbidimetric assay. The effects of compound Danshen injection combined with magnesium sulfate on the above indexes were observed. Serum levels of MPO and hs-CRP significantly decreased in early-onset observation, late-onset observation, early-onset control and late-onset control groups after treatment (p<0.05). After treatment, levels of MPO and hs-CRP were significantly lower in early-onset observation group than in early-onset control group (p<0.05), and levels of MPO and hs-CRP were also significantly lower in late-onset observation group than in late-onset control group (p<0.05). Total effective rate of early-onset observation group and late‑onset observation group were higher than that of early‑onset control group and late-onset control group. Compound Danshen injection combined with magnesium sulfate achieved better treatment outcomes in the treatment of severe PE than magnesium sulfate alone. The combined treatment can effectively reduce the serum levels of MPO and hs-CRP.

References

1 

Spaan JJ, Houben AJ, Musella A, Ekhart T, Spaanderman ME and Peeters LL: Insulin resistance relates to microvascular reactivity 23 years after preeclampsia. Microvasc Res. 80:417–421. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Miyakoshi K, Ishimoto H, Nishimura O, Tanigaki S, Tanaka M, Miyazaki T, Natori M and Yoshimura Y: Role of leukocytes in uterine hypoperfusion and fetal growth retardation induced by ischemia-reperfusion. Am J Physiol Heart Circ Physiol. 280:H1215–H1221. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Cebesoy FB, Balat O, Dikensoy E, Kalayci H and Ibar Y: CA-125 and CRP are elevated in preeclampsia. Hypertens Pregnancy. 28:201–211. 2009. View Article : Google Scholar : PubMed/NCBI

4 

De Silva DA, Eghdami L, McKeever M, Lee T, Tu D, Hutcheon J, Pv D, Liston R and Magee L: A causal model of magnesium sulphate use in women hospitalized at <9 weeks with severe or non-severe pre-eclampsia. Pregnancy Hypertens. 5:19–20. 2015. View Article : Google Scholar

5 

Hladunewich MA, Kingdom J, Odutayo A, Burns K, Lai V, O'Brien T, Gandhi S, Zimpelmann J, Kiss A, Miller J, et al: Postpartum assessment of the renin angiotensin system in women with previous severe, early-onset preeclampsia. J Clin Endocrinol Metab. 96:3517–3524. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Doumatey AP, Zhou J, Adeyemo A and Rotimi C: High sensitivity C-reactive protein (Hs-CRP) remains highly stable in long-term archived human serum. Clin Biochem. 47:315–318. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Rosa JS, Oliver SR, Flores RL, Ngo J, Milne GL, Zaldivar FP and Galassetti PR: Altered inflammatory, oxidative, and metabolic responses to exercise in pediatric obesity and type 1 diabetes. Pediatr Diabetes. 12:464–472. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Ertas IE, Kahyaoglu S, Yilmaz B, Ozel M, Sut N, Guven MA and Danisman N: Association of maternal serum high sensitive C-reactive protein level with body mass index and severity of pre-eclampsia at third trimester. J Obstet Gynaecol Res. 36:970–977. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Vaerland IE, Vevatne K and Brinchmann BS: Mothers' experiences of having a premature infant due to pre-eclampsia. Scand J Caring Sci. August 10–2017.(Epub ahead of print). doi: 10.1111/scs.12476. View Article : Google Scholar : PubMed/NCBI

10 

Ren-an Q, Juan L, Chuyuan L, Wenjuan F, Chunyan H, Xuemei Y, Lin H and Hong N: Study of the protective mechanisms of Compound Danshen Tablet (Fufang Danshen Pian) against myocardial ischemia/reperfusion injury via the Akt-eNOS signaling pathway in rats. J Ethnopharmacol. 156:190–198. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Saver JL, Starkman S, Eckstein M, Stratton SJ, Pratt FD, Hamilton S, Conwit R, Liebeskind DS, Sung G, Kramer I, et al: FAST-MAG Investigators and Coordinators: Prehospital use of magnesium sulfate as neuroprotection in acute stroke. N Engl J Med. 372:528–536. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Carè A, Catalucci D, Felicetti F, Bonci D, Addario A, Gallo P, Bang ML, Segnalini P, Gu Y, Dalton ND, et al: MicroRNA-133 controls cardiac hypertrophy. Nat Med. 13:613–618. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Rahimi Z, Rahimi Z, Aghaei A and Vaisi-Raygani A: AT2R-1332 G:A polymorphism and its interaction with AT1R 1166 A:C, ACE I/D and MMP-9-1562 C:T polymorphisms: risk factors for susceptibility to preeclampsia. Gene. 538:176–181. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Ndoni E, Hoxhallari R and Bimbashi A: Evaluation of maternal complications in severe preeclampsia in a university hospital in Tirana. Open Access Maced J Med Sci. 4:102–106. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Prefumo F and Farina A: Screening for pre-eclampsia in the first trimester: What do we still need to know before starting? Ultrasound Obstet Gynecol. 50:662–663. 2017.simplehttps://doi.org/10.1002/uog.18893 View Article : Google Scholar : PubMed/NCBI

16 

Tong CX, Xing XF, Qiao SH, Liu L and Shan L: Effect of low molecular weight heparin calcium combined compound danshen injection on perinatal outcomes of nephrotic syndrome patients with early onset severe pre-eclampsia. Zhongguo Zhong Xi Yi Jie He Za Zhi. 35:957–961. 2015.(In Chinese). PubMed/NCBI

17 

Mizutani S and Mizutani E: New insights into the role of sex steroid hormones in pregnancy: Possible therapeutic approach by sex steroid hormones for the treatment of both preeclampsia and preterm labor. Exp Clin Endocrinol Diabetes. 123:159–164. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Golden MH: Nutritional and other types of oedema, albumin, complex carbohydrates and the interstitium - a response to Malcolm Coulthard's hypothesis: Oedema in kwashiorkor is caused by hypo-albuminaemia. Paediatr Int Child Health. 35:90–109. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Rajendran P, Rengarajan T, Thangavel J, Nishigaki Y, Sakthisekaran D, Sethi G and Nishigaki I: The vascular endothelium and human diseases. Int J Biol Sci. 9:1057–1069. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Ndoni E, Hoxhallari R and Bimbashi A: Evaluation of maternal complications in severe preeclampsia in a university hospital in Tirana. Open Access Maced J Med Sci. 4:102–106. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Lees C and Ferrazzi E: Relevance of haemodynamics in treating pre-eclampsia. Curr Hypertens Rep. 19:762017. View Article : Google Scholar : PubMed/NCBI

22 

Holmes D: Diabetes: Falling insulin requirements - a red flag for pre-eclampsia. Nat Rev Endocrinol. 13:5632017. View Article : Google Scholar

23 

Liu YK, Liu ML, Wang YH, Chen H, Meng LL and Zhang JP: Role of CCL17 and CCL22 expression in dendritic cells in maternal-fetal immune tolerance. Chin J Pahophysiol. 28:1061–1065. 2012.

24 

Salonen I, Huttunen K, Hirvonen MR, Dufva J, Groundstroem K, Dufva H, Pekkanen J and Salonen RO: Serum myeloperoxidase is independent of the risk factors of atherosclerosis. Coron Artery Dis. 23:251–258. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Alsuwaida A, Mousa D, Al-Harbi A, Alghonaim M, Ghareeb S and Alrukhaimi MN: Impact of early chronic kidney disease on maternal and fetal outcomes of pregnancy. J Matern Fetal Neonatal Med. 24:1432–1436. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
APA
Yang, K., Dong, G., Tian, Y., & Li, J. (2018). Effects of compound Danshen injection combined with magnesium sulfate on serum MPO and hs-CRP in patients with severe preeclampsia. Experimental and Therapeutic Medicine, 16, 167-170. https://doi.org/10.3892/etm.2018.6173
MLA
Yang, K., Dong, G., Tian, Y., Li, J."Effects of compound Danshen injection combined with magnesium sulfate on serum MPO and hs-CRP in patients with severe preeclampsia". Experimental and Therapeutic Medicine 16.1 (2018): 167-170.
Chicago
Yang, K., Dong, G., Tian, Y., Li, J."Effects of compound Danshen injection combined with magnesium sulfate on serum MPO and hs-CRP in patients with severe preeclampsia". Experimental and Therapeutic Medicine 16, no. 1 (2018): 167-170. https://doi.org/10.3892/etm.2018.6173