Treatment of severe periodontic‑endodontic combined lesions with minocycline hydrochloride ointment combined with mineral trioxide aggregate

Shao,Wen; Xiao,Feng; Xu,Zhong‑Xin; Ren,Rui‑Han; Wang,Yong; Wu,Yi‑Qun

doi:10.3892/etm.2018.6341

Treatment of severe periodontic‑endodontic combined lesions with minocycline hydrochloride ointment combined with mineral trioxide aggregate

Authors:
- Wen Shao
- Feng Xiao
- Zhong‑Xin Xu
- Rui‑Han Ren
- Yong Wang
- Yi‑Qun Wu
View Affiliations

Affiliations: The 2nd Dental Center, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, P.R. China, Department of Dentistry, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230600, P.R. China, Department of Counterterrorism Research, Zhejiang Police College, Hangzhou, Zhejiang 310053, P.R. China, Department of Dentistry, People's Hospital of Linyi, Linyi, Shandong 276000, P.R. China, Department of Oral and Maxillofacial Surgery, The Ninth People's Hospital, College of Stomatology, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai 200011, P.R. China
Published online on: June 21, 2018 https://doi.org/10.3892/etm.2018.6341
Pages: 1389-1396

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Periodontic‑endodontic combined lesions affect the quality of life of patients. The present study aimed to explore a way to achieve maximal effect in treating periodontic‑endodontic combined lesions by using a combination of minocycline hydrochloride ointment (MHO) and mineral trioxide aggregate (MTA). In the present study, 294 patients were randomly divided into four groups: Control group, MHO group, MTA group and combination group. Endodontic and periodontic therapy was applied simultaneously on the anterior and posterior teeth of patients, and patient characteristics, gingival index (GI) and probing depth (PD) were noted when the patients were treated with the different strategies. Reexamination was performed 4 weeks after treatment and follow‑up was performed 2 years later. The present study demonstrated that medical history, root filling and periapical condition within the patients were deemed as key factors in determining the success of treatment of periodontic‑endodontic combined lesions. The effect of the combination treatment significantly exceeded that of either treatment alone (P<0.05). In addition, the teeth were significantly improved for patients with pathological types I, II and III in the combination group compared with either treatment group alone (P<0.05). Furthermore, compared with the MTA and MHO groups alone, the combination group demonstrated a significant decrease in PD and GI in severe periodontic‑endodontic combined lesions. In conclusion, the present findings implied that combination treatment is significantly superior to single treatments applied to patients with severe periodontic‑endodontic combined lesions.

View Figures

View References

1	Raheja J, Tewari S, Tewari S and Duhan J: Evaluation of efficacy of chlorhexidine intracanal medicament on the periodontal healing of concomitant endodontic-periodontal lesions without communication: An interventional study. J Periodontol. 85:1019–1026. 2014. View Article : Google Scholar : PubMed/NCBI
2	Huffaker SK, Safavi K, Spangberg LS and Kaufman B: Influence of a passive sonic irrigation system on the elimination of bacteria from root canal systems: A clinical study. J Endod. 36:1315–1318. 2010. View Article : Google Scholar : PubMed/NCBI
3	Zimet PO and Endo C: Preservation of the roots-management and prevention protocols for cracked tooth syndrome. Ann R Australas Coll Dent Surg. 15:319–324. 2000.PubMed/NCBI
4	Torabinejad M, Watson TF and Ford Pitt TR: Sealing ability of a mineral trioxide aggregate when used as a root end filling material. J Endod. 19:591–595. 1993. View Article : Google Scholar : PubMed/NCBI
5	Lee SJ, Monsef M and Torabinejad M: Sealing ability of a mineral trioxide aggregate for repair of lateral root perforations. J Endod. 19:541–544. 1993. View Article : Google Scholar : PubMed/NCBI
6	Sluyk SR, Moon PC and Hartwell GR: Evaluation of setting properties and retention characteristics of mineral trioxide aggregate when used as a furcation perforation repair material. J Endod. 24:768–771. 1998. View Article : Google Scholar : PubMed/NCBI
7	Karygianni L, Proksch S, Schneider S, Vach K, Hellwig E, Steinberg T, Schulz SD, Tchorz JP and Altenburger MJ: The effects of various mixing solutions on the biocompatibility of mineral trioxide aggregate. Int Endod J. 49:561–573. 2016. View Article : Google Scholar : PubMed/NCBI
8	Prasad A, Pushpa S, Arunagiri D, Sawhny A, Misra A and Sujatha R: A comparative evaluation of the effect of various additives on selected physical properties of whitemineral trioxide aggregate. J Conserv Dent. 18:237–241. 2015. View Article : Google Scholar : PubMed/NCBI
9	Moore A, Howley MF and O'Connell AC: Treatment of open apex teeth using two types of white mineral trioxide aggregate after initial dressing with calcium hydroxide in children. Dent Traumatol. 27:166–173. 2011. View Article : Google Scholar : PubMed/NCBI
10	Agamy HA, Bakry NS, Mounir MM and Avery DR: Comparison of mineral trioxide aggregate and formocresol as pulp-capping agents in pulpotomized primary teeth. Pediatr Dent. 26:302–309. 2004.PubMed/NCBI
11	Challenger H, Lane J, Becker R, Nassiripour S and Torabinejad M: Dye leakage and modification of fast-setting mineral trioxide aggregate. J Calif Dent Assoc. 43:82–86. 2015.PubMed/NCBI
12	Ravindran S and George A: Biomimetic extracellular matrix mediated somatic stem cell differentiation: Applications in dental pulptissue regeneration. Front Physiol. 6:1182015. View Article : Google Scholar : PubMed/NCBI
13	Giovanella LB, Barletta FB, Felippe WT, Bruno KF, De Alencar AH and Estrela C: Assessment of oxygen saturation in dental pulp of permanent teeth with periodontal disease. J Endod. 40:1927–1931. 2014. View Article : Google Scholar : PubMed/NCBI
14	Xia X, Huang BX, Zhu WD and Meng HX: Effect of minocycline hydrochloride ointment on cell attachment and proliferation on titanium disks. Zhonghua Kou Qiang Yi Xue Za Zhi. 47:518–522. 2012.(In Chinese). PubMed/NCBI
15	Nakao R, Takigawa S, Sugano N, Koshi R, Ito K, Watanabe H and Senpuku H: Impact of minocycline ointment for periodontal treatment of oral bacteria. Jpn J Infect Dis. 64:156–160. 2011.PubMed/NCBI
16	Shigeyama M, Ohgaya T, Kawashima Y, Takeuchi H and Hino T: Modification of the physicochemical properties of minocycline hydrochloride ointment with cyclodextrines for optimum treatment of bedsore. Chem Pharm Bull (Tokyo). 48:617–622. 2000. View Article : Google Scholar : PubMed/NCBI
17	Shigeyama M, Ohgaya T, Kawashima Y, Takeuchi H and Hino T: Mixed base of hydrophilic ointment and purified lanolin to improve the drug release rate and absorption of water of minocycline hydrochloride ointment for treatment of bedsores. Chem Pharm Bull (Tokyo). 47:744–748. 1999. View Article : Google Scholar : PubMed/NCBI
18	Mazur B and Massler M: Influence of periodontal diseases on the dental pulp. Oral Surg Oral Med Oral Pathol. 17:592–603. 1964. View Article : Google Scholar : PubMed/NCBI
19	Rotstein I and Simon JH: Diagnosis, prognosis and decision-making in the treatment of combined periodontal-endodontic lesions. Periodontol 2000. 34:165–203. 2004. View Article : Google Scholar : PubMed/NCBI
20	Walter C, Krastl G and Weiger R: Step-wise treatment of two periodontal-endodontic lesions in a heavy smoker. Int Endod J. 41:1015–1023. 2008. View Article : Google Scholar : PubMed/NCBI
21	Marques JH, Silva-Sousa YT, Rached-Júnior FJ, Mazzi-Chaves JF, Miranda CE, Da Silva SR, Steier L and Sousa-Neto MD: New methodology to evaluate bond strength of root-end filling materials. Braz Dent J. 26:288–291. 2015. View Article : Google Scholar : PubMed/NCBI
22	Lahor-Soler E, Miranda-Rius J, Brunet-Llobet L, Farré M and Pumarola J: In vitro study of the apical microleakage with resilon root canal filling using different final endodontic irrigants. J Clin Exp Dent. 7:e212–e217. 2015. View Article : Google Scholar : PubMed/NCBI
23	Prestegaard H, Portenier I, Ørstavik D, Kayaoglu G, Haapasalo M and Endal U: Antibacterial activity of various root canal sealers and root-end filling materials in dentin blocks infected ex vivo with Enterococcus faecalis. Acta Odontol Scand. 72:970–976. 2014. View Article : Google Scholar : PubMed/NCBI
24	Patel SP, Kalra N, Pradeep AR, Martande SS, Naik SB, Raju AP and Singh P: Association of metabolic syndrome and periodontal disease in an Indian population. J Int Acad Periodontol. 16:98–1028. 2014.PubMed/NCBI
25	AL Shayeb KN, Turner W and Gillam DG: Accuracy and reproducibility of probe forces during simulated periodontal pocket depthmeasurements. Saudi Dent J. 26:50–55. 2014. View Article : Google Scholar : PubMed/NCBI
26	Ishihata K, Wakabayashi N, Wadachi J, Akizuki T, Izumi Y, Takakuda K and Igarashi Y: Reproducibility of probing depth measurement by an experimental periodontal probe incorporating optical fiber sensor. J Periodontol. 83:222–227. 2012. View Article : Google Scholar : PubMed/NCBI
27	Geng S, Cao C and Chen Z: The effect of non-surgical periodontal and adjunctive minocycline-HCL treatments on collagenase activity. Zhonghua Kou Qiang Yi Xue Za Zhi. 35:336–339. 2000.(In Chinese). PubMed/NCBI
28	Hajishengallis G, Abe T, Maekawa T, Hajishengallis E and Lambris JD: Role of complement in host-microbe homeostasis of the periodontium. Semin Immunol. 25:65–72. 2013. View Article : Google Scholar : PubMed/NCBI
29	Anand PS, Kamath KP, Bansal A, Dwivedi S and Anil S: Comparison of periodontal destruction patterns among patients with and without the habit of smokeless tobacco use-a retrospective study. J Periodontal Res. 48:623–631. 2013. View Article : Google Scholar : PubMed/NCBI
30	Messora MR, Oliveira LF, Foureaux RC, Taba M JR, Zangerônimo MG, Furlaneto FA and Pereira LJ: Probiotic therapy reduces periodontal tissue destruction and improves the intestinal morphology in rats with ligature-induced periodontitis. J Periodontol. 84:1818–1826. 2013. View Article : Google Scholar : PubMed/NCBI
31	Konermann A, Al-Malat R, Skupin J, Keilig L, Dirk C, Karanis R, Bourauel C and Jäger A: In vivo determination of tooth mobility after fixed orthodontic appliance therapy with a novel intraoral measurement device. Clin Oral Investig. 21:1283–1289. 2017. View Article : Google Scholar : PubMed/NCBI