The relationship between inflammatory factor expression and blood pressure and urinary protein in the placenta of gestational hypertension rats

Jia,Xue-Qin; Xu,Su; Tian,Mei-Rong; Ma,Yu-Yan

doi:10.3892/etm.2018.6668

The relationship between inflammatory factor expression and blood pressure and urinary protein in the placenta of gestational hypertension rats

Authors:
- Xue-Qin Jia
- Su Xu
- Mei-Rong Tian
- Yu-Yan Ma
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Affiliations: Department of Obstetrics, Qilu Hospital of Shandong University, Jinan, Shandong 250010, P.R. China, Department of Obstetrics, The Lanshan District Maternal and Child Care Service Centre of Rizhao, Rizhao, Shandong 276812, P.R. China, Department Obstetrics, Taian City Central Hospital, Taian, Shandong 271000, P.R. China
Published online on: August 30, 2018 https://doi.org/10.3892/etm.2018.6668
Pages: 3793-3798
Copyright: © Jia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The association between inflammatory factor expression and blood pressure with urinary protein in the placenta of pregnant women with pregnancy-induced hypertension (PIH) was investigated to provide a new vision for the clinical prevention and treatment of PIH. Rats were used as animal models and were randomly divided into three groups (control, hypertension and treatment groups) on day 15 of pregnancy with 20 rats in each group. The 10% hypoxia-induced PIH group was induced with administration of an anti-hypertensive drug, and the treatment group was giventreprostinil for one week after the 10% hypoxia-induced PIH. On the 21st day, the experiment was terminated and the placenta was taken to measure the mRNA and protein expression levels of IL-6 and TNF-α, respectively. Pearson's correlation analysis demonstrated the correlation between IL-6 and TNF-α with blood pressure and urinary protein. The blood pressure and urinary protein concentrations in the hypertension group were significantly higher than that in the control group, and the expression levels of IL-6 and TNF-α in the hypertension group were significantly higher (P<0.05). The treatment group significantly reduced inflammatory cytokines and blood pressure and urinary protein levels (P<0.05). Pearson's correlation analysis showed that IL-6 and TNF-α were positively correlated with blood pressure and urinary protein concentration. The blood pressure and urinary protein concentration in PIH rats and the expression levels of IL-6 and TNF-α were significantly higher, and IL-6 and TNF-α were positively correlated with blood pressure and urine protein concentration.

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