Open Access

Type A aortic dissection in pregnant patients with fibrillin‑1 gene mutations: Two case reports and a literature review

  • Authors:
    • Yuanli Lei
    • Zhelong Jiang
    • Jiaozhen Chen
    • Dongsheng Wang
    • Guangliang Hong
    • Shouquan Chen
  • View Affiliations

  • Published online on: September 19, 2018     https://doi.org/10.3892/etm.2018.6761
  • Pages: 4407-4414
  • Copyright: © Lei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In acute aortic dissection (AD) in pregnancy, increased cardiovascular stress due to pregnancy is an important factor leading to an emergent aortic event. It is rare but often results in a devastating event for both the pregnant patient and the foetus. Two cases of acute AD (Stanford type A) in pregnant females are presented in the present study. The patients were diagnosed via echocardiography, and the diagnosis was confirmed with computed tomography angiography prior to aortic surgery. Up to 50% of ADs in pregnancy occur in patients with fibrillin‑1 (FBN1) gene mutations. The FBN1 gene was sequenced in both patients, and notable, novel pathogenic mutations of FBN1 were identified in both patients. A literature review was also performed on available diagnostic imaging and other measurements regarding AD during pregnancy. The authors suggest that the relevant content may have important clinical implications in raising disease awareness, arranging test rationally and choosing an intervention method.
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December-2018
Volume 16 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Lei Y, Jiang Z, Chen J, Wang D, Hong G and Chen S: Type A aortic dissection in pregnant patients with fibrillin‑1 gene mutations: Two case reports and a literature review. Exp Ther Med 16: 4407-4414, 2018.
APA
Lei, Y., Jiang, Z., Chen, J., Wang, D., Hong, G., & Chen, S. (2018). Type A aortic dissection in pregnant patients with fibrillin‑1 gene mutations: Two case reports and a literature review. Experimental and Therapeutic Medicine, 16, 4407-4414. https://doi.org/10.3892/etm.2018.6761
MLA
Lei, Y., Jiang, Z., Chen, J., Wang, D., Hong, G., Chen, S."Type A aortic dissection in pregnant patients with fibrillin‑1 gene mutations: Two case reports and a literature review". Experimental and Therapeutic Medicine 16.6 (2018): 4407-4414.
Chicago
Lei, Y., Jiang, Z., Chen, J., Wang, D., Hong, G., Chen, S."Type A aortic dissection in pregnant patients with fibrillin‑1 gene mutations: Two case reports and a literature review". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4407-4414. https://doi.org/10.3892/etm.2018.6761