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Antimicrobial resistance in bacterial pathogens among hospitalised patients with severe invasive infections

  • Authors:
    • Ovidiu Zlatian
    • Andrei Theodor Balasoiu
    • Maria Balasoiu
    • Oana Cristea
    • Anca Oana Docea
    • Radu Mitrut
    • Demetrios A. Spandidos
    • Aristides M. Tsatsakis
    • Gabriela Bancescu
    • Daniela Calina

  • View Affiliations

  • Published online on: September 14, 2018     https://doi.org/10.3892/etm.2018.6737
  • Pages: 4499-4510

  • Copyright: © Zlatian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The most severe infections are invasive infections, due to the fact that the germs can accumulate in multiple sites and produce a body-wide infection known as sepsis. Septic shock has the highest mortality rate among non-traumatic medical conditions. In this study, we aimed to evaluate the incidence and prevalence of invasive infections in a hospital environment. Another second objective was to establish the aetiology of invasive infections in our hospital and the antibiotic resistance profile of the germs involved, which are both important for determining the therapeutic approach for the treatment of these infections. The study included 505 hospitalized patients from which we collected a total of 974 blood cultures. For the analysis of the blood cultures, we used an automated incubator. The bottles flagged as positive were subcultured on blood agar, and the grown colonies were identified using an identification system. Invasive infections had a prevalence rate of 27.72% in our hospital. From the 974 blood cultures, we isolated 170 bacterial strains: Staphylococcus aureus (SA; 63 strains, 37.06%), Klebsiella spp. (27 strains, 15.88%), coagulase-negative staphylococci (CoNS; 18 strains, 10.59%), Enterococcus spp. (17 strains, 10.00%), Escherichia coli (12 strains, 7.06%), Streptococcus spp. (11 strains, 6.47%) and other bacterial species. The prevalence of methicillin-resistant SA (MRSA) in our study was 36.51% from the SA strains. The MRSA prevalence differed significantly according to age (37.50% in adults vs. 28.57% in children, P=0.047) and ICU admission (42.42% in ICU patients vs. 30.00% in non-ICU patients, P=0.018). We performed a multivariate analysis of the invasive infection risk which detected as significant predictors the admission into the cardiology ward and plastic surgery ward. On the whole, the findings of this study indicate that the high prevalence of Gram-positive cocci in blood cultures, mostly SA, with multidrug resistance has important consequences for the management of invasive infections.
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December-2018
Volume 16 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zlatian O, Balasoiu AT, Balasoiu M, Cristea O, Docea AO, Mitrut R, Spandidos DA, Tsatsakis AM, Bancescu G, Calina D, Calina D, et al: Antimicrobial resistance in bacterial pathogens among hospitalised patients with severe invasive infections. Exp Ther Med 16: 4499-4510, 2018
APA
Zlatian, O., Balasoiu, A.T., Balasoiu, M., Cristea, O., Docea, A.O., Mitrut, R. ... Calina, D. (2018). Antimicrobial resistance in bacterial pathogens among hospitalised patients with severe invasive infections. Experimental and Therapeutic Medicine, 16, 4499-4510. https://doi.org/10.3892/etm.2018.6737
MLA
Zlatian, O., Balasoiu, A. T., Balasoiu, M., Cristea, O., Docea, A. O., Mitrut, R., Spandidos, D. A., Tsatsakis, A. M., Bancescu, G., Calina, D."Antimicrobial resistance in bacterial pathogens among hospitalised patients with severe invasive infections". Experimental and Therapeutic Medicine 16.6 (2018): 4499-4510.
Chicago
Zlatian, O., Balasoiu, A. T., Balasoiu, M., Cristea, O., Docea, A. O., Mitrut, R., Spandidos, D. A., Tsatsakis, A. M., Bancescu, G., Calina, D."Antimicrobial resistance in bacterial pathogens among hospitalised patients with severe invasive infections". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4499-4510. https://doi.org/10.3892/etm.2018.6737