Efficacy of intravenous lidocaine in improving post‑operative nausea, vomiting and early recovery after laparoscopic gynaecological surgery

Wang,Tao; Liu,Hui; Sun,Jian  Hong; Wang,Lin; Zhang,Jian  You

doi:10.3892/etm.2019.7497

Efficacy of intravenous lidocaine in improving post‑operative nausea, vomiting and early recovery after laparoscopic gynaecological surgery

Authors:
- Tao Wang
- Hui Liu
- Jian Hong Sun
- Lin Wang
- Jian You Zhang
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Affiliations: Department of Anesthesia, Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu 225000, P.R. China, Department of Endocrinology, Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu 225000, P.R. China
Published online on: April 17, 2019 https://doi.org/10.3892/etm.2019.7497
Pages: 4723-4729

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Abstract

Post‑operative nausea and vomiting (PONV) is a major peri‑operative complication. It has numerous adverse consequences that seriously affect the post‑operative recovery of patients. The aim of the present study was to investigate the efficacy of intravenous lidocaine in improving PONV and recovery after laparoscopic gynaecological surgery. A total of 40 patients were randomly assigned to 2 groups: Group L (lidocaine group) and Group C (control group). The patients in Group L received intravenous lidocaine throughout the operation, while patients in Group C were given a saline infusion. Vital signs, recovery time, extubation time, dosage of remifentanil, first flatus time and defecation time of each patient were recorded. The incidence of PONV after surgery was also recorded. The recovery of the patients was evaluated by using the quality of recovery score (QoR‑40). The total dose of remifentanil was signiﬁcantly lower in Group L (P<0.05). However, the recovery time and extubation time were shorter in Group C (P<0.05). The first flatus time and defecation time were longer in Group C (P<0.05). The mean arterial pressure and heart rate in Group L were lower and more stable (P<0.05). At 6 h after surgery, the incidence of PONV was signiﬁcantly lower in Group L vs. that in Group C (P<0.05). The QoR‑40 score in Group C was signiﬁcantly lower at 1 and 3 days after the operation compared with that in Group C (P<0.05). In conclusion, intravenous lidocaine administered to patients undergoing laparoscopic gynaecological surgery may reduce PONV and supports their early recovery [trial registration number in Chinese Clinical Trial Registry: ChiCTR‑IOR‑17010782 (March 5, 2017)].

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