Study of the analgesic activities, chronic toxicity and addictive potential of Jia-Yuan-Qing pill in rats

  • Authors:
    • Ye Tian
    • Li‑Rong Teng
    • Zhen‑Zuo Wang
    • Min Zhao
    • Qing‑Fan Meng
    • Jia‑Hui Lu
    • Jian‑Ming Tian
    • Wei‑Wei Zhang
    • Xiaoyi Zheng
    • Di Wang
    • Le‑Sheng Teng
  • View Affiliations

  • Published online on: April 15, 2015     https://doi.org/10.3892/etm.2015.2426
  • Pages: 2349-2355
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Abstract

Jia-Yuan-Qing pill (JYQP) composed of Porcellio laevis Latreille, Corydalis Rhizoma and Radix Cynanchi Paniculati at a ratio of 9:7:7 has been found to be an effective analgesic agent. The present study aimed to evaluate the safety, addictive potential and anti-cancer pain activity of JYQP in a rat model. During the 6‑month chronic toxicity test, no significant changes in general behavior, defecation, postural abnormalities, dietary or water intake or blood biochemical parameters were observed in male and female rats. Although a high dose of JYQP (5 g/kg) caused swelling of the liver, spleen and kidney in male and female rats, no pathological changes were observed in all organs examined via hematoxylin and eosin staining. The analgesic effect of JYQP on bone cancer pain was successfully confirmed in a rat model of Walker 256 cell‑induced bone cancer. In contrast to morphine, in a physical dependence test, JYQP produced no withdrawal symptoms following chronic administration. The data from this study provide experimental evidence supporting the clinical use of JYQP as an effective, safe and non-addictive agent for the treatment of bone cancer pain.
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June-2015
Volume 9 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Tian Y, Teng LR, Wang ZZ, Zhao M, Meng QF, Lu JH, Tian JM, Zhang WW, Zheng X, Wang D, Wang D, et al: Study of the analgesic activities, chronic toxicity and addictive potential of Jia-Yuan-Qing pill in rats. Exp Ther Med 9: 2349-2355, 2015
APA
Tian, Y., Teng, L., Wang, Z., Zhao, M., Meng, Q., Lu, J. ... Teng, L. (2015). Study of the analgesic activities, chronic toxicity and addictive potential of Jia-Yuan-Qing pill in rats. Experimental and Therapeutic Medicine, 9, 2349-2355. https://doi.org/10.3892/etm.2015.2426
MLA
Tian, Y., Teng, L., Wang, Z., Zhao, M., Meng, Q., Lu, J., Tian, J., Zhang, W., Zheng, X., Wang, D., Teng, L."Study of the analgesic activities, chronic toxicity and addictive potential of Jia-Yuan-Qing pill in rats". Experimental and Therapeutic Medicine 9.6 (2015): 2349-2355.
Chicago
Tian, Y., Teng, L., Wang, Z., Zhao, M., Meng, Q., Lu, J., Tian, J., Zhang, W., Zheng, X., Wang, D., Teng, L."Study of the analgesic activities, chronic toxicity and addictive potential of Jia-Yuan-Qing pill in rats". Experimental and Therapeutic Medicine 9, no. 6 (2015): 2349-2355. https://doi.org/10.3892/etm.2015.2426