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A further case of acute myelomonocytic leukemia with inv(8) chromosomal rearrangement and MOZ-NCOA2 gene fusion

  • Authors:
    • Anne Murati
    • José Adélaïde
    • Cornel Popovici
    • Marie-Joëlle Mozziconacci
    • Christine Arnoulet
    • Marina Lafage-Pochitaloff
    • Danielle Sainty
    • Daniel Birnbaum
    • Max Chaffanet

  • View Affiliations

  • Published online on: October 1, 2003     https://doi.org/10.3892/ijmm.12.4.423
  • Pages: 423-428
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Abstract

We report here the sixth case of acute monoblastic leukemia associated with the inv(8)(p11q13) pericentric inversion. As seen in the previous cases, the inv(8)(p11q13) molecular characterization showed that the alteration results in a MOZ-NCOA2 gene fusion. The presence of erythrophagocytosis is a distinctive morphologic feature that is observed in all patients with MOZ alteration. However, the relative young age of the 6 patients (median: 23.5 years) and same sex (female) are the common characteristics that are only observed in the inv(8)-positive leukemia subgroup. In addition, we tested whether the presence of FLT3 internal duplications (ITD) are frequently found in malignant hemopathies with 8p11-12 rearrangements. We did not find any FLT3 ITD in any of the studied cases.

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Journal Cover

October 2003
Volume 12 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 10.7
  • CiteScore Rank: Q1: #35/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.994
  • SCImago Journal Rank (SJR): 0.922
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Spandidos Publications style
Murati A, Adélaïde J, Popovici C, Mozziconacci M, Arnoulet C, Lafage-Pochitaloff M, Sainty D, Birnbaum D and Chaffanet M: A further case of acute myelomonocytic leukemia with inv(8) chromosomal rearrangement and MOZ-NCOA2 gene fusion. Int J Mol Med 12: 423-428, 2003
APA
Murati, A., Adélaïde, J., Popovici, C., Mozziconacci, M., Arnoulet, C., Lafage-Pochitaloff, M. ... Chaffanet, M. (2003). A further case of acute myelomonocytic leukemia with inv(8) chromosomal rearrangement and MOZ-NCOA2 gene fusion. International Journal of Molecular Medicine, 12, 423-428. https://doi.org/10.3892/ijmm.12.4.423
MLA
Murati, A., Adélaïde, J., Popovici, C., Mozziconacci, M., Arnoulet, C., Lafage-Pochitaloff, M., Sainty, D., Birnbaum, D., Chaffanet, M."A further case of acute myelomonocytic leukemia with inv(8) chromosomal rearrangement and MOZ-NCOA2 gene fusion". International Journal of Molecular Medicine 12.4 (2003): 423-428.
Chicago
Murati, A., Adélaïde, J., Popovici, C., Mozziconacci, M., Arnoulet, C., Lafage-Pochitaloff, M., Sainty, D., Birnbaum, D., Chaffanet, M."A further case of acute myelomonocytic leukemia with inv(8) chromosomal rearrangement and MOZ-NCOA2 gene fusion". International Journal of Molecular Medicine 12, no. 4 (2003): 423-428. https://doi.org/10.3892/ijmm.12.4.423