Open Access

Lipid metabolic pathways as lung cancer therapeutic targets: A computational study

  • Authors:
    • Kojiro Yano
  • View Affiliations

  • Published online on: December 30, 2011     https://doi.org/10.3892/ijmm.2011.876
  • Pages: 519-529
  • Copyright: © Yano . This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Inhibitors of lipid metabolic pathways, particularly drugs targeting the mevalonate pathway, have been suggested to be valuable in enhancing the effectiveness of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) and these compounds may also be effective in patients with inherent or acquired resistance to EGFR-TKIs. The present study examined gene expression profiles in lung adenocarcinoma to characterize the interaction between growth factor signals and lipid metabolic pathways at the transcriptional level. Gene expression correlation analysis showed that genes involved in the mevalonate pathway and unsaturated fatty acid synthesis were negatively correlated with the expression of EGFR, MET and other growth factor receptor genes, as well as with the expression of genes involved in cell migration and adhesion. On the other hand, the expression of genes related to cell cycle progression, DNA repair and DNA replication were positively correlated with the metabolic pathway genes mentioned above, and a significant number of such genes had promoter domains for nuclear factor Y (NFY). Genes whose expression showed a positive correlation with NFY expression and mevalonate pathway genes were found to exhibit protein-protein interactions with several ‘hub’ genes, including BRCA1, that have been associated with both lung cancer and cell division. These results support the idea that inhibition of lipid metabolic pathways may be valuable as an alternative therapeutic option for the treatment of lung adenocarcinoma, and suggest that NFY is a possible molecular target for such efforts.
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April 2012
Volume 29 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Yano K: Lipid metabolic pathways as lung cancer therapeutic targets: A computational study. Int J Mol Med 29: 519-529, 2012
APA
Yano, K. (2012). Lipid metabolic pathways as lung cancer therapeutic targets: A computational study. International Journal of Molecular Medicine, 29, 519-529. https://doi.org/10.3892/ijmm.2011.876
MLA
Yano, K."Lipid metabolic pathways as lung cancer therapeutic targets: A computational study". International Journal of Molecular Medicine 29.4 (2012): 519-529.
Chicago
Yano, K."Lipid metabolic pathways as lung cancer therapeutic targets: A computational study". International Journal of Molecular Medicine 29, no. 4 (2012): 519-529. https://doi.org/10.3892/ijmm.2011.876