Nanog and β-catenin: A new convergence point in EpSC proliferation and differentiation

  • Authors:
    • Delong Yin
    • Linqiang Tian
    • Yaping Ye
    • Kunpeng Li
    • Jiang Wang
    • Peng Cheng
    • Anmin Chen
    • Fengjing Guo
    • Hui Huang
  • View Affiliations

  • Published online on: December 29, 2011     https://doi.org/10.3892/ijmm.2011.871
  • Pages: 587-592
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Abstract

Skin tissue homeostasis is maintained by the balanced proliferation and differentiation of certain types of proliferating cells such as epidermal stem cells (EpSCs). The proliferation and differentiation of EpSCs are complex processes which are not well understood. This study aimed to find the internal relationship between the Nanog pathway and the Wnt/β-catenin pathway in the proliferation and differentiation process of EpSCs. In brief, EpSCs were isolated from rat epidermis and cultured. The MTT assay, western blotting, polymerase chain reaction (PCR) and immunocytochemistry were performed during the proliferation and differentiation process of EpSCs. Our results showed that 10-7 M neuropeptide substance P could effectively stimulate proliferation of EpSCs and that a possible link exists between the Nanog pathway and the Wnt/β-catenin pathway.
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April 2012
Volume 29 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Yin D, Tian L, Ye Y, Li K, Wang J, Cheng P, Chen A, Guo F and Huang H: Nanog and β-catenin: A new convergence point in EpSC proliferation and differentiation. Int J Mol Med 29: 587-592, 2012
APA
Yin, D., Tian, L., Ye, Y., Li, K., Wang, J., Cheng, P. ... Huang, H. (2012). Nanog and β-catenin: A new convergence point in EpSC proliferation and differentiation. International Journal of Molecular Medicine, 29, 587-592. https://doi.org/10.3892/ijmm.2011.871
MLA
Yin, D., Tian, L., Ye, Y., Li, K., Wang, J., Cheng, P., Chen, A., Guo, F., Huang, H."Nanog and β-catenin: A new convergence point in EpSC proliferation and differentiation". International Journal of Molecular Medicine 29.4 (2012): 587-592.
Chicago
Yin, D., Tian, L., Ye, Y., Li, K., Wang, J., Cheng, P., Chen, A., Guo, F., Huang, H."Nanog and β-catenin: A new convergence point in EpSC proliferation and differentiation". International Journal of Molecular Medicine 29, no. 4 (2012): 587-592. https://doi.org/10.3892/ijmm.2011.871