N GalièMM HoeperM HumbertGuidelines for the diagnosis and treatment of pulmonary hypertensionEur Heart J30249325372009

VV McLaughlinSL ArcherDB BadeschACCF/AHA 2009 expert consensus document on pulmonary hypertensionCirculation11922502294200910.1161/CIRCULATIONAHA.109.192230

S StewartD RasslAdvances in the understanding and classification of pulmonary hypertensionHistopathology54104116200910.1111/j.1365-2559.2008.03180.x19187180

M HumbertNW MorrellSL ArcherKR StenmarkMR MacLeanIM LangBW ChristmanEK WeirO EickelbergNF VoelkelM RabinovitchCellular and molecular pathobiology of pulmonary arterial hypertensionJ Am Coll Cardiol43Suppl 12S13S24200410.1016/j.jacc.2004.02.02915194174

M MandegarYC FungW HuangCV RemillardLJ RubinJX YuanCellular and molecular mechanisms of pulmonary vascular remodeling: role in the development of pulmonary hypertensionMicrovasc Res6875103200410.1016/j.mvr.2004.06.00115313118

E GurbanovX ShiliangThe key role of apoptosis in the pathogenesis and treatment of pulmonary hypertensionEur J Cardiothorac Surg30499507200610.1016/j.ejcts.2006.05.02616870458

SL ArcherEK WeirMR WilkinsBasic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapiesCirculation12120452066201010.1161/CIRCULATIONAHA.108.84770720458021

NW MorrellS AdnotSL ArcherCellular and molecular basis of pulmonary arterial hypertensionJ Am Coll Cardiol54Suppl 1S20S31200910.1016/j.jacc.2009.04.01819555855

T UechiT TanakaN KenmochiA complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disordersGenomics72223230200110.1006/geno.2000.647011401437

Y ZhangGW WolfK BhatA JinT AllioWA BurkhartY XiongRibosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathwayMol Cell Biol2389028912200310.1128/MCB.23.23.8902-8912.200314612427

HT GazdaMR SheenA VlachosV ChoesmelMF O’DonohueH SchneiderN DarrasC HasmanCA SieffPE NewburgerRibosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patientsAm J Hum Genet83769780200810.1016/j.ajhg.2008.11.00419061985

Y Ofir-RosenfeldK BoggsD MichaelMB KastanM OrenMdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26Mol Cell32180189200810.1016/j.molcel.2008.08.03118951086

SJ AndersonJP LauritsenMG HartmanAM FousheeJM LefebvreSA ShintonB GerhardtRR HardyT OraveczDL WiestAblation of ribosomal protein L22 selectively impairs αβ T cell development by activation of a p53-dependent checkpointImmunity26759772200717555992

Z PanJ HuangW CuiC LongY ZhangH WangTargeting hypertension with a new adenosine triphosphate-sensitive potassium channel opener iptakalimJ Cardiovasc Pharmacol56215228201010.1097/FJC.0b013e3181e23e2b20410832

H WangY TangYL ZhangHypoxic pulmonary hypertension (HPH) and iptakalim, a novel ATP-sensitive potassium channel opener targeting smaller arteries in hypertensionCardiovasc Drug Rev23293316200510.1111/j.1527-3466.2005.tb00174.x16614730

MX YangZX LiuS ZhangY JingSJ ZhangWP XieL MaCL ZhuH WangProteomic analysis of the effect of iptakalim on human pulmonary arterial smooth muscle cell proliferationActa Pharmacol Sin30175183200910.1038/aps.2008.3019169269

YM ZhuSJ ZhangWP XieQL LiYJ ZhouH WangIptakalim inhibited endothelin-1-induced proliferation of human pulmonary arterial smooth muscle cells through the activation of K_ATP channelVascul Pharmacol489299200810.1016/j.vph.2008.01.00118276195

S SakaoK TatsumiNF VoelkelEndothelial cells and pulmonary arterial hypertension: apoptosis, proliferation, interaction and transdifferentiationRespir Res1095103200910.1186/1465-9921-10-95

MR MacleanY DempsieThe serotonin hypothesis of pulmonary hypertension revisitedAdv Exp Med Biol661309322201010.1007/978-1-60761-500-2_2020204739

ED BurgCV RemillardJX YuanPotassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis: pharmacotherapeutic implicationsBr J Pharmacol153Suppl 1S99S111200810.1038/sj.bjp.070763518084317

YY ZhaoAB MalikA novel insight into the mechanism of pulmonary hypertension involving caveolin-1 deficiency and endothelial nitric oxide synthase activationTrends Cardiovasc Med19238242200910.1016/j.tcm.2010.02.00320382348

L Taraseviciene-StewartY KasaharaL AlgerP HirthG McMahonJ WaltenbergerNF VoelkelRM TuderInhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell deathdependent pulmonary endothelial cell proliferation and severe pulmonary hypertensionFASEB J15427438200110.1096/fj.00-0343com11156958

RT SchermulyE DonyHA GhofraniS PullamsettiR SavaiM RothA SydykovYJ LaiN WeissmannW SeegerF GrimmingerReversal of experimental pulmonary hypertension by PDGF inhibitionJ Clin Invest11528112821200510.1172/JCI2483816200212

G LagnaPH NguyenW NiA HataBMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cellsAm J Physiol Lung Cell Mol Physiol291L1059L1067200610.1152/ajplung.00180.200617030903

WP XieH WangJH DingH WangG HuAnti-proliferating effect of iptakalim, a novel K_ATP channel opener, in cultured rabbit pulmonary arterial smooth muscle cellsEur J Pharmacol5118187200510.1016/j.ejphar.2005.01.039

B RohitMT RubinMH PaulEndothelial dysfunction in pulmonary hypertensionCirculation109159165200410.1161/01.CIR.0000102381.57477.5014734504

N DavieSJ HaleenPD UptonJM PolakMH YacoubNW MorrellJ WhartonET_A and ETB receptors modulate the proliferation of human pulmonary artery smooth muscle cellsAm J Respir Crit Care Med1653984052002

E TronicDJ WebbEndothelium-derived endothelin-1Pflug Arch Eur J Phy459951958201010.1007/s00424-009-0763-y

I KomuroH KuriharaT SugiyamaM YoshizumiF TakakuY YazakiEndothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cellsFEBS Lett238249252198810.1016/0014-5793(88)80489-73139457

RP JankovC KantoresR BelcastroM YiAK TanswellEndothelin-1 inhibits apoptosis of pulmonary arterial smooth muscle in the neonatal ratPediatr Res60245251200610.1203/01.pdr.0000233056.37254.0b16857764

S RobledoRA IdolDL CrimminsJH LadensonPJ MasonM BesslerThe role of human ribosomal proteins in the maturation of rRNA and ribosome productionRNA1419181929200810.1261/rna.113200818697920

D Hernandez-VerdunAssembly and disassembly of the nucleolus during the cell cycleNucleus2189194201110.4161/nucl.2.3.1624621818412

DW StaceyCyclin D1 serves as a cell cycle regulatory switch in actively proliferating cellsCurr Opin Cell Biol15158163200310.1016/S0955-0674(03)00008-512648671

KA McGowanJZ LiCY ParkV BeaudryHK TaborAJ SabnisW ZhangH FuchsMH de AngelisRM MyersRibosomal mutations cause p53-mediated dark skin and pleiotropic effectsNat Genet40963970200810.1038/ng.18818641651