Elucidating the regulation of T cell subsets (Review)

  • Authors:
    • Yasuko Kitagishi
    • Mayumi Kobayashi
    • Yurie Yamashina
    • Satoru Matsuda
  • View Affiliations

  • Published online on: October 9, 2012     https://doi.org/10.3892/ijmm.2012.1152
  • Pages: 1255-1260
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Abstract

CD4-positive T lymphocytes mainly direct immune as well as autoimmune responses against a variety of pathogens or allergens. This is achieved through the acquisition of specialized functions followed by differentiation into various T cell subsets. The differentiation process of naive T cells into effector subsets is regulated by dendritic cells and secreted cytokines. Signal transducer and activator of transcription proteins play critical roles in transmitting cytokine-mediated signals and specifying T cell differentiation. Epigenetic changes such as histone acetylation and methylation along with DNA methylation also regulate expression of differentiation-specific genes. Defining exactly how extrinsic signals control the specification of T cells will provide important insights and therapeutic opportunities.
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December 2012
Volume 30 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Kitagishi Y, Kobayashi M, Yamashina Y and Matsuda S: Elucidating the regulation of T cell subsets (Review). Int J Mol Med 30: 1255-1260, 2012
APA
Kitagishi, Y., Kobayashi, M., Yamashina, Y., & Matsuda, S. (2012). Elucidating the regulation of T cell subsets (Review). International Journal of Molecular Medicine, 30, 1255-1260. https://doi.org/10.3892/ijmm.2012.1152
MLA
Kitagishi, Y., Kobayashi, M., Yamashina, Y., Matsuda, S."Elucidating the regulation of T cell subsets (Review)". International Journal of Molecular Medicine 30.6 (2012): 1255-1260.
Chicago
Kitagishi, Y., Kobayashi, M., Yamashina, Y., Matsuda, S."Elucidating the regulation of T cell subsets (Review)". International Journal of Molecular Medicine 30, no. 6 (2012): 1255-1260. https://doi.org/10.3892/ijmm.2012.1152