Bambusae Caulis in Taeniam modulates neuroprotective and anti-neuroinflammatory effects in hippocampal and microglial cells via HO-1- and Nrf-2-mediated pathways

  • Authors:
    • Hye Won Eom
    • Sun Young Park
    • Young Hun Kim
    • Su Jin Seong
    • Mei Ling Jin
    • Eun Yeon Ryu
    • Min Ju Kim
    • Sang Joon Lee
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  • Published online on: September 18, 2012     https://doi.org/10.3892/ijmm.2012.1128
  • Pages: 1512-1520
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Abstract

Recent evidence indicates that microglial activation and hippocampal damage may play important roles in neurodegenerative diseases, including Alzheimer's disease. Bambusae Caulis in Taeniam has been used as a folk remedy for the treatment of hypertension and cardiovascular disease in China and Korea. In this study, the mechanism responsible for the neuroprotective and anti-neuroinflammatory effects of Bambusae Caulis in Taeniam ethyl acetate fraction (BCE) was investigated. Heme oxygenase-1 (HO-1) is an inducible enzyme expressed in response to various inflammatory stimuli. Due to its role in the anti-inflammatory signaling pathway, the expression and modulation of HO-1 are important. In this study, the neuroprotective and anti-neuroinflammatory effects of BCE were examined using the murine microglial BV2 and hippocampal HT22 cells. We demonstrated that the administration of BCE provided neuroprotective effects against glutamate-induced cytotoxicity in HT22 cells through the HO-1 and nuclear erythroid-2 related factor 2 (Nrf-2) signaling pathways. We also reported that BCE inhibited lipopolysaccharide (LPS)-induced pro-inflammatory cytokines and that the presence of selective inhibitors of HO-1 (SnPP) resulted in the inhibition of BCE-mediated anti-inflammatory activity in BV2 microglial cells. BCE was shown to induce HO-1 expression as well as the nuclear translocation of Nrf-2 in both microglial and hippocampal cells. These findings revealed the potential therapeutic mechanisms of BCE in neurodegenerative diseases, suggesting that HO-1 and Nrf-2 signaling may play important roles in the mediation of its neuroprotective and anti-neuroinflammatory effects.
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December 2012
Volume 30 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Eom HW, Park SY, Kim YH, Seong SJ, Jin ML, Ryu EY, Kim MJ and Lee SJ: Bambusae Caulis in Taeniam modulates neuroprotective and anti-neuroinflammatory effects in hippocampal and microglial cells via HO-1- and Nrf-2-mediated pathways. Int J Mol Med 30: 1512-1520, 2012.
APA
Eom, H.W., Park, S.Y., Kim, Y.H., Seong, S.J., Jin, M.L., Ryu, E.Y. ... Lee, S.J. (2012). Bambusae Caulis in Taeniam modulates neuroprotective and anti-neuroinflammatory effects in hippocampal and microglial cells via HO-1- and Nrf-2-mediated pathways. International Journal of Molecular Medicine, 30, 1512-1520. https://doi.org/10.3892/ijmm.2012.1128
MLA
Eom, H. W., Park, S. Y., Kim, Y. H., Seong, S. J., Jin, M. L., Ryu, E. Y., Kim, M. J., Lee, S. J."Bambusae Caulis in Taeniam modulates neuroprotective and anti-neuroinflammatory effects in hippocampal and microglial cells via HO-1- and Nrf-2-mediated pathways". International Journal of Molecular Medicine 30.6 (2012): 1512-1520.
Chicago
Eom, H. W., Park, S. Y., Kim, Y. H., Seong, S. J., Jin, M. L., Ryu, E. Y., Kim, M. J., Lee, S. J."Bambusae Caulis in Taeniam modulates neuroprotective and anti-neuroinflammatory effects in hippocampal and microglial cells via HO-1- and Nrf-2-mediated pathways". International Journal of Molecular Medicine 30, no. 6 (2012): 1512-1520. https://doi.org/10.3892/ijmm.2012.1128