Novel rotundic acid derivatives: Synthesis, structural characterization and in vitro antitumor activity

  • Authors:
    • Yu Chen
    • Yu-Fang He
    • Min-Lun Nan
    • Wen-Yi Sun
    • Jie Hu
    • Ai Cui
    • Fan Li
    • Fang Wang
  • View Affiliations

  • Published online on: December 6, 2012     https://doi.org/10.3892/ijmm.2012.1206
  • Pages: 353-360
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Six novel rotundic acid (RA, 1) derivatives 4a-4f modified at the 28-COOH position were synthesized, and their structures were confirmed by IR, MS, 1H NMR and 13C NMR. The derivatives were evaluated for cytotoxic properties on the following three tumor cell lines: HeLa, HepG2 and SGC-7901. Compound 4f showed better cytotoxic activity compared with RA treatment and lower IC50 (4.16 µM) on HepG2 cells than on HeLa (8.54 µM) and SGC-7901 cells (11.32 µM). The anticancer mechanism of compound 4f was studied through cell cycle progression and apoptosis. Notably, compound 4f was able to induce apoptosis and G0/G1 cell cycle arrest of HepG2 at a concentration of 4.16 µM. In summary, RA was modified to obtain six novel derivatives. Compound 4f exhibited better cytotoxicity and may be developed as a potential agent against hepatocellular carcinoma.
View Figures
View References

Related Articles

Journal Cover

February 2013
Volume 31 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Chen Y, He Y, Nan M, Sun W, Hu J, Cui A, Li F and Wang F: Novel rotundic acid derivatives: Synthesis, structural characterization and in vitro antitumor activity. Int J Mol Med 31: 353-360, 2013.
APA
Chen, Y., He, Y., Nan, M., Sun, W., Hu, J., Cui, A. ... Wang, F. (2013). Novel rotundic acid derivatives: Synthesis, structural characterization and in vitro antitumor activity. International Journal of Molecular Medicine, 31, 353-360. https://doi.org/10.3892/ijmm.2012.1206
MLA
Chen, Y., He, Y., Nan, M., Sun, W., Hu, J., Cui, A., Li, F., Wang, F."Novel rotundic acid derivatives: Synthesis, structural characterization and in vitro antitumor activity". International Journal of Molecular Medicine 31.2 (2013): 353-360.
Chicago
Chen, Y., He, Y., Nan, M., Sun, W., Hu, J., Cui, A., Li, F., Wang, F."Novel rotundic acid derivatives: Synthesis, structural characterization and in vitro antitumor activity". International Journal of Molecular Medicine 31, no. 2 (2013): 353-360. https://doi.org/10.3892/ijmm.2012.1206