Protective effects of nimodipine on cerebrovascular function in chronic alcoholic encephalopathy

Li,Hui; Yang,Xue; Shi,Wei; Ma,Zhao; Feng,Guangshen; Wang,Qinzhou; Shen,Li; Xie,Chunli

doi:10.3892/ijmm.2013.1540

Protective effects of nimodipine on cerebrovascular function in chronic alcoholic encephalopathy

Authors:
- Hui Li
- Xue Yang
- Wei Shi
- Zhao Ma
- Guangshen Feng
- Qinzhou Wang
- Li Shen
- Chunli Xie
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Affiliations: Department of Neurology, Jinan Fourth People's Hospital, Jinan, Shandong, P.R. China, Department of Neurology, Shandong University Qilu Hospital, Jinan, Shandong, P.R. China, Department of Gynecotokology, Jinan Central Hospital, Jinan, Shandong, P.R. China, Department of Emergency, Jinan Fourth People's Hospital, Jinan, Shandong, P.R. China, Clinical Laboratory, Jinan Fourth People's Hospital, Jinan, Shandong, P.R. China
Published online on: October 30, 2013 https://doi.org/10.3892/ijmm.2013.1540
Pages: 201-208

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Abstract

In the present study, we used chronic gavage administration of alcohol with gradual increases in alcohol concentration and volume to generate a rat model of chronic alcohol intoxication. We measured the changes in biological, behavioral, pathological and vascular injury-related molecular biological markers, and explored the effects of nimodipine intervention on alcohol intoxication. We found that chronic alcohol consumption induced a variety of behavioral abnormalities, accompanied by severe pathological changes in cerebral arterioles, prefrontal cortex and cerebellar tissue, as well as an upregulation of vascular endothelial growth factor (VEGF), leptin receptor (ob-R) and endothelin-1 (ET-1). Treatment with mimodipine for 15 days significantly improved behavioral abnormalities, alleviated the pathological changes in blood vessels and brain tissues, increased VEGF expression, decreased ob-R expression, reduced plasma ET-1 leakage and protected vascular and neuronal functions.

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