Open Access

Expression, regulation and mechanism of action of the miR-17-92 cluster in tumor cells (Review)

  • Authors:
    • Li-Li Fang
    • Xing-Hui Wang
    • Bao-Fei Sun
    • Xiao-Dong Zhang
    • Xu-Hui Zhu
    • Zi-Jiang Yu
    • Heng Luo
  • View Affiliations

  • Published online on: September 29, 2017     https://doi.org/10.3892/ijmm.2017.3164
  • Pages:1624-1630
  • Copyright: © Fang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNAs (miRNAs), a class of short, single‑stranded non‑coding RNAs, regulate and control gene expression in eukaryotes by degrading mRNA at the post‑transcriptional level. Regulation by miRNAs involves a plethora of biological processes, such as cell differentiation, proliferation, metastasis, metabolism, apoptosis, tumorigenesis and others. miRNAs also represent a powerful tool in disease diagnosis and prognosis. The miR‑17‑92 cluster, one of the most extensively investigated microRNA clusters, comprises six mature miRNA members, including miR‑17, miR‑18a, miR‑19a, miR‑19b, miR‑20a and miR‑92a. Originally identified as being involved in tumorigenesis, it is currently evident that the expression of the miR‑17‑92 cluster is upregulated in a wide range of tumor cells and cancer types; thus, this cluster has been identified as a potential oncogene. Considering the growing interest in the field of miR‑17‑92 research, we herein review recent advances in the expression and regulation of this cluster in various cancer cells, discuss the proposed mechanism of action for tumorigenesis and tumor development, and propose clinical and therapeutic applications for miR‑17‑92 cluster members, such as potential cancer biomarkers.

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December 2017
Volume 40 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

2016 Impact Factor: 2.341
Ranked #21/128 Medicine Research and Experimental
(total number of cites)

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Copy and paste a formatted citation
APA
Fang, L., Wang, X., Sun, B., Zhang, X., Zhu, X., Yu, Z., & Luo, H. (2017). Expression, regulation and mechanism of action of the miR-17-92 cluster in tumor cells (Review). International Journal of Molecular Medicine, 40, 1624-1630. https://doi.org/10.3892/ijmm.2017.3164
MLA
Fang, L., Wang, X., Sun, B., Zhang, X., Zhu, X., Yu, Z., Luo, H."Expression, regulation and mechanism of action of the miR-17-92 cluster in tumor cells (Review)". International Journal of Molecular Medicine 40.6 (2017): 1624-1630.
Chicago
Fang, L., Wang, X., Sun, B., Zhang, X., Zhu, X., Yu, Z., Luo, H."Expression, regulation and mechanism of action of the miR-17-92 cluster in tumor cells (Review)". International Journal of Molecular Medicine 40, no. 6 (2017): 1624-1630. https://doi.org/10.3892/ijmm.2017.3164