Open Access

The role and mechanism of β‑arrestins in cancer invasion and metastasis (Review)

  • Authors:
    • Qing Song
    • Qing Ji
    • Qi Li
  • View Affiliations

  • Published online on: November 27, 2017     https://doi.org/10.3892/ijmm.2017.3288
  • Pages:631-639
  • Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

β‑arrestins are a family of adaptor proteins that regulate the signaling and trafficking of various G protein‑coupled receptors (GPCRs). They consist of β‑arrestin1 and β‑arrestin2 and are considered to be scaffolding proteins. β‑arrestins regulate cell proliferation, promote cell invasion and migration, transmit anti‑apoptotic survival signals and affect other characteristics of tumors, including tumor growth rate, angiogenesis, drug resistance, invasion and metastatic potential. It has been demonstrated that β‑arrestins serve roles in various physiological and pathological processes and exhibit a similar function to GPCRs. β‑arrestins serve primary roles in cancer invasion and metastasis via various signaling pathways. The present review assessed the function and mechanism of β‑arrestins in cancer invasion and metastasis via multiple signaling pathways, including mitogen‑activated protein kinase/extracellular signal regulated kinase, Wnt/β‑catenin, nuclear factor‑κB and phosphoinositide‑3 kinase/Akt.

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Journal Cover

February 2018
Volume 41 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

2016 Impact Factor: 2.341
Ranked #21/128 Medicine Research and Experimental
(total number of cites)

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APA
Song, Q., Ji, Q., & Li, Q. (2018). The role and mechanism of β‑arrestins in cancer invasion and metastasis (Review). International Journal of Molecular Medicine, 41, 631-639. https://doi.org/10.3892/ijmm.2017.3288
MLA
Song, Q., Ji, Q., Li, Q."The role and mechanism of β‑arrestins in cancer invasion and metastasis (Review)". International Journal of Molecular Medicine 41.2 (2018): 631-639.
Chicago
Song, Q., Ji, Q., Li, Q."The role and mechanism of β‑arrestins in cancer invasion and metastasis (Review)". International Journal of Molecular Medicine 41, no. 2 (2018): 631-639. https://doi.org/10.3892/ijmm.2017.3288