Open Access

REG3A overexpression suppresses gastric cancer cell invasion, proliferation and promotes apoptosis through PI3K/Akt signaling pathway

  • Authors:
    • Yan-Song Qiu
    • Guang-Jun Liao
    • Ning-Ning Jiang
  • View Affiliations

  • Published online on: February 28, 2018     https://doi.org/10.3892/ijmm.2018.3520
  • Pages: 3167-3174
  • Copyright: © Qiu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastric cancer (GC) is the second most common cause of cancer-related deaths. In recent years some essential factors for resolution were identified, but the clinical trials still lack the effective methods to treat or monitor the disease progression. Regenerating islet-derived 3α (REG3A) is a member of REG protein family. Previous studies have investigated the altered expression of REG3A in various cancers. In this investigtion we aimed at the biological function and the underlying molecular mechanism of REG3A in GC. We found that REG3A was significantly downregulated in GC and closely related with patient prognoses. REG3A overexpression suppressed the invasion and proliferation promoting apoptosis of GC cells. While REG3A knockdown promoted the invasion, and proliferation suppressing apoptosis of GC cells. It was further found that REG3A performed its biological functions mainly through phosphatidylinositol 3 kinase (PI3K)/Akt-GSK3β signaling pathway axis. REG3A may be a promising therapeutic strategy for GC.
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June-2018
Volume 41 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Qiu Y, Liao G and Jiang N: REG3A overexpression suppresses gastric cancer cell invasion, proliferation and promotes apoptosis through PI3K/Akt signaling pathway. Int J Mol Med 41: 3167-3174, 2018
APA
Qiu, Y., Liao, G., & Jiang, N. (2018). REG3A overexpression suppresses gastric cancer cell invasion, proliferation and promotes apoptosis through PI3K/Akt signaling pathway. International Journal of Molecular Medicine, 41, 3167-3174. https://doi.org/10.3892/ijmm.2018.3520
MLA
Qiu, Y., Liao, G., Jiang, N."REG3A overexpression suppresses gastric cancer cell invasion, proliferation and promotes apoptosis through PI3K/Akt signaling pathway". International Journal of Molecular Medicine 41.6 (2018): 3167-3174.
Chicago
Qiu, Y., Liao, G., Jiang, N."REG3A overexpression suppresses gastric cancer cell invasion, proliferation and promotes apoptosis through PI3K/Akt signaling pathway". International Journal of Molecular Medicine 41, no. 6 (2018): 3167-3174. https://doi.org/10.3892/ijmm.2018.3520