Open Access

Caspase recruitment domains for protein interactions in cellular signaling (Review)

  • Authors:
    • Hyun Ho Park
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  • Published online on: January 11, 2019     https://doi.org/10.3892/ijmm.2019.4060
  • Pages: 1119-1127
  • Copyright: © Park . This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The caspase recruitment domain (CARD), a well‑known protein interaction module, belongs to the death domain (DD) superfamily, which includes DDs, death effector domains, and pyrin domains. The DD superfamily mediates the protein interactions necessary for apoptosis and immune cell signaling pathways. Among these domains, the CARD has been studied extensively as it mediates important cellular signaling events that are associated with various human diseases including cancer, neuro‑degenerative diseases and immune disorders. Homo‑type and hetero‑type CARD‑CARD interactions mediate the formation of large signaling complexes, including caspase‑activating complexes and downstream signaling complexes. The present review summarizes and discusses the results of structural studies of various CARDs and their complexes. These studies shed light on the mechanisms that control the assembly and disassembly of signaling complexes and provide an improved understanding of cellular signaling processes.
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March-2019
Volume 43 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Park HH: Caspase recruitment domains for protein interactions in cellular signaling (Review). Int J Mol Med 43: 1119-1127, 2019
APA
Park, H.H. (2019). Caspase recruitment domains for protein interactions in cellular signaling (Review). International Journal of Molecular Medicine, 43, 1119-1127. https://doi.org/10.3892/ijmm.2019.4060
MLA
Park, H. H."Caspase recruitment domains for protein interactions in cellular signaling (Review)". International Journal of Molecular Medicine 43.3 (2019): 1119-1127.
Chicago
Park, H. H."Caspase recruitment domains for protein interactions in cellular signaling (Review)". International Journal of Molecular Medicine 43, no. 3 (2019): 1119-1127. https://doi.org/10.3892/ijmm.2019.4060