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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2005 Volume 26 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2005 Volume 26 Issue 3

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Article

Comparative genomic hybridization of human breast epithelial cells transformed by estrogen and its metabolites

  • Authors:
    • Sandra V. Fernandez
    • Irma H. Russo
    • Mohamed Lareef
    • Binaifer Balsara
    • Jose Russo

  • View Affiliations / Copyright

    Affiliations: Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA, USA
  • Pages: 691-695
    |
    Published online on: March 1, 2005
       https://doi.org/10.3892/ijo.26.3.691
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Abstract

The elevated incidence of breast cancer in women has been associated with prolonged exposure to high levels of estrogens. Our laboratory has demonstrated that treatment of the immortalized human breast epithelial cells MCF-10F with 17β-estradiol (E2) or its metabolites 4-hydroxy-estradiol (4-OH-E2) and 2-hydroxy-estradiol (2-OH-E2) induces phenotypical changes indicative of neoplastic transformation. The MCF-10F cells treated with E2, 2-OH-E2 and 4-OH-E2 form colonies in agar methocel and lost their ductulogenic capacity in collagen matrix, expressing phenotypes similar to those induced by the carcinogen benz(a)pyrene (BP). To investigate whether these phenotypic changes were associated with genomic changes, MCF-10F cells treated with either E2, 2-OH-E2, or 4-OH-E2 at different doses (0.007 nM, 70 nM and 3.6 µM) were analyzed using a combination of standard G-banding and comparative genomic hybridization (CGH). Whereas no aneuploidy was observed in any of the transformed cells, the CGH revealed instead that only cells treated with 4-OH-E2 at the highest concentration (3.6 µM) exhibited DNA gains at 8q24, 9q34 and 20q13 and losses at 13q21.

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Copy and paste a formatted citation
Spandidos Publications style
Fernandez SV, Russo IH, Lareef M, Balsara B and Russo J: Comparative genomic hybridization of human breast epithelial cells transformed by estrogen and its metabolites. Int J Oncol 26: 691-695, 2005.
APA
Fernandez, S.V., Russo, I.H., Lareef, M., Balsara, B., & Russo, J. (2005). Comparative genomic hybridization of human breast epithelial cells transformed by estrogen and its metabolites. International Journal of Oncology, 26, 691-695. https://doi.org/10.3892/ijo.26.3.691
MLA
Fernandez, S. V., Russo, I. H., Lareef, M., Balsara, B., Russo, J."Comparative genomic hybridization of human breast epithelial cells transformed by estrogen and its metabolites". International Journal of Oncology 26.3 (2005): 691-695.
Chicago
Fernandez, S. V., Russo, I. H., Lareef, M., Balsara, B., Russo, J."Comparative genomic hybridization of human breast epithelial cells transformed by estrogen and its metabolites". International Journal of Oncology 26, no. 3 (2005): 691-695. https://doi.org/10.3892/ijo.26.3.691
Copy and paste a formatted citation
x
Spandidos Publications style
Fernandez SV, Russo IH, Lareef M, Balsara B and Russo J: Comparative genomic hybridization of human breast epithelial cells transformed by estrogen and its metabolites. Int J Oncol 26: 691-695, 2005.
APA
Fernandez, S.V., Russo, I.H., Lareef, M., Balsara, B., & Russo, J. (2005). Comparative genomic hybridization of human breast epithelial cells transformed by estrogen and its metabolites. International Journal of Oncology, 26, 691-695. https://doi.org/10.3892/ijo.26.3.691
MLA
Fernandez, S. V., Russo, I. H., Lareef, M., Balsara, B., Russo, J."Comparative genomic hybridization of human breast epithelial cells transformed by estrogen and its metabolites". International Journal of Oncology 26.3 (2005): 691-695.
Chicago
Fernandez, S. V., Russo, I. H., Lareef, M., Balsara, B., Russo, J."Comparative genomic hybridization of human breast epithelial cells transformed by estrogen and its metabolites". International Journal of Oncology 26, no. 3 (2005): 691-695. https://doi.org/10.3892/ijo.26.3.691
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