Depletion of Treg cells inhibits minimal residual disease after surgery of HPV16-associated tumours

  • Authors:
    • Jana Símová
    • Jan Bubeník
    • Jana Bieblová
    • Rodney Alexander Rosalia
    • Jan Fric
    • Milan Reinis
  • View Affiliations

  • Published online on: December 1, 2006     https://doi.org/10.3892/ijo.29.6.1567
  • Pages: 1567-1571
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Abstract

It is generally accepted that T regulatory cells (Treg CD4+CD25+Foxp3+) play an important role in the suppression of tumour immunity. We examined the impact of Treg cell depletion with anti-CD25 antibody as adjuvant therapy in the treatment of minimal residual disease after excision of murine HPV16-associated tumours. We found that the depletion of Treg cells inhibited growth of the recurrences after surgery of HPV16-associated MHC class I+ as well as MHC class I-deficient tumours transplanted in syngeneic mice. These results demonstrate that depletion of CD25+CD4+ Treg cells can be used as an efficient adjuvant treatment improving the results of surgery in the experimental systems mimicking human MHC class I+ and MHC class I-deficient, HPV16-associated neoplasms. Therefore, this therapeutic modality is worth being examined in patients with minimal residual HPV16-associated tumour disease after surgery.

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December 2006
Volume 29 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Símová, J., Bubeník, J., Bieblová, J., Rosalia, R.A., Fric, J., & Reinis, M. (2006). Depletion of Treg cells inhibits minimal residual disease after surgery of HPV16-associated tumours. International Journal of Oncology, 29, 1567-1571. https://doi.org/10.3892/ijo.29.6.1567
MLA
Símová, J., Bubeník, J., Bieblová, J., Rosalia, R. A., Fric, J., Reinis, M."Depletion of Treg cells inhibits minimal residual disease after surgery of HPV16-associated tumours". International Journal of Oncology 29.6 (2006): 1567-1571.
Chicago
Símová, J., Bubeník, J., Bieblová, J., Rosalia, R. A., Fric, J., Reinis, M."Depletion of Treg cells inhibits minimal residual disease after surgery of HPV16-associated tumours". International Journal of Oncology 29, no. 6 (2006): 1567-1571. https://doi.org/10.3892/ijo.29.6.1567