microRNA-372 maintains oncogene characteristics by targeting TNFAIP1 and affects NFκB signaling in human gastric carcinoma cells

Zhou,Chang; Li,Xiaofeng; Zhang,Xiaoting; Liu,Xizhi; Tan,Zhiwen; Yang,Celi; Zhang,Jian

doi:10.3892/ijo.2012.1737

microRNA-372 maintains oncogene characteristics by targeting TNFAIP1 and affects NFκB signaling in human gastric carcinoma cells

Authors:
- Chang Zhou
- Xiaofeng Li
- Xiaoting Zhang
- Xizhi Liu
- Zhiwen Tan
- Celi Yang
- Jian Zhang
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Affiliations: Key Laboratory of Protein Chemistry and Developmental Biology of State Education Ministry of China, College of Life Science, Hunan Normal University, Changsha, Hunan 410081, P.R. China
Published online on: December 13, 2012 https://doi.org/10.3892/ijo.2012.1737
Pages: 635-642

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Abstract

Aberrant microRNA (miRNA) expression has been investigated in gastric cancer, which is one of the most common malignancies. However, the roles of miRNAs in gastric cancer remain largely unknown. In the present study, we found that microRNA-372 (miR-372) directly targets tumor necrosis factor, α-induced protein 1 (TNFAIP1), and is involved in the regulation of the NFκB signaling pathway. Furthermore, overexpression of TNFAIP1 induced changes in AGS cells similar to those in AGS cells treated with miR-372-ASO. Collectively, these findings demonstrate an oncogenic role for miR-372 in controlling cell growth and apoptosis through downregulation of TNFAIP1. This novel molecular basis provides new insights into the etiology of gastric cancer.

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