A dynamic interplay between alternative polyadenylation and microRNA regulation: Implications for cancer (Review)

  • Authors:
    • Jindan An
    • Xiaodong Zhu
    • Hongwei Wang
    • Xiudong Jin
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  • Published online on: August 1, 2013     https://doi.org/10.3892/ijo.2013.2047
  • Pages: 995-1001
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Abstract

Alternative polyadenylation and microRNA regulation are both mechanisms of post-transcriptional regulation of gene expression. Alternative polyadenylation often results in mRNA isoforms with the same coding sequence but different lengths of 3' UTRs, while microRNAs regulate gene expression by binding to specific mRNA 3' UTRs. In this sense, different isoforms of an mRNA may be differentially regulated by microRNAs, sometimes resulting in cellular proliferation and this mechanism is being speculated on as a potential cause for cancer development.
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October 2013
Volume 43 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
An J, Zhu X, Wang H and Jin X: A dynamic interplay between alternative polyadenylation and microRNA regulation: Implications for cancer (Review). Int J Oncol 43: 995-1001, 2013.
APA
An, J., Zhu, X., Wang, H., & Jin, X. (2013). A dynamic interplay between alternative polyadenylation and microRNA regulation: Implications for cancer (Review). International Journal of Oncology, 43, 995-1001. https://doi.org/10.3892/ijo.2013.2047
MLA
An, J., Zhu, X., Wang, H., Jin, X."A dynamic interplay between alternative polyadenylation and microRNA regulation: Implications for cancer (Review)". International Journal of Oncology 43.4 (2013): 995-1001.
Chicago
An, J., Zhu, X., Wang, H., Jin, X."A dynamic interplay between alternative polyadenylation and microRNA regulation: Implications for cancer (Review)". International Journal of Oncology 43, no. 4 (2013): 995-1001. https://doi.org/10.3892/ijo.2013.2047