Notch and Wnt signaling pathway in cancer: Crucial role and potential therapeutic targets (Review)

  • Authors:
    • Yu-Feng Xiao
    • Xin Yong
    • Bo Tang
    • Yong Qin
    • Jian-Wei Zhang
    • Dan Zhang
    • Rui Xie
    • Shi-Ming Yang
  • View Affiliations

  • Published online on: December 7, 2015     https://doi.org/10.3892/ijo.2015.3280
  • Pages: 437-449
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Abstract

There is no radical cure for all cancer types. The most frequently used therapies are surgical treatment, radiotherapy and chemotherapy. However, recrudescence, radiation resistance and chemotherapy resistance are the most challenging issues in clinical practice. To address these issues, they should be further studied at the molecular level, and the signaling pathways involved represent a promising avenue for this research. In the present review, we mainly discuss the components and mechanisms of activation of the Notch and Wnt signaling pathways, and we summarize the recent research efforts on these two pathways in different cancers. We also evaluate the ideal drugs that could target these two signaling pathways for cancer therapy, summarize alterations in the Notch and Wnt signaling pathways in cancer, and discuss potential signaling inhibitors as effective drugs for cancer therapy.
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February 2016
Volume 48 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
APA
Xiao, Y., Yong, X., Tang, B., Qin, Y., Zhang, J., Zhang, D. ... Yang, S. (2016). Notch and Wnt signaling pathway in cancer: Crucial role and potential therapeutic targets (Review). International Journal of Oncology, 48, 437-449. https://doi.org/10.3892/ijo.2015.3280
MLA
Xiao, Y., Yong, X., Tang, B., Qin, Y., Zhang, J., Zhang, D., Xie, R., Yang, S."Notch and Wnt signaling pathway in cancer: Crucial role and potential therapeutic targets (Review)". International Journal of Oncology 48.2 (2016): 437-449.
Chicago
Xiao, Y., Yong, X., Tang, B., Qin, Y., Zhang, J., Zhang, D., Xie, R., Yang, S."Notch and Wnt signaling pathway in cancer: Crucial role and potential therapeutic targets (Review)". International Journal of Oncology 48, no. 2 (2016): 437-449. https://doi.org/10.3892/ijo.2015.3280