Upregulation of metastasis-associated PRL-3 initiates chordoma in zebrafish

  • Authors:
    • Li Li
    • Hongshun Shi
    • Mingming Zhang
    • Xiaoling Guo
    • Fang Tong
    • Wenliang Zhang
    • Junyi Zhou
    • Haihe Wang
    • Shulan Yang
  • View Affiliations

  • Published online on: January 29, 2016     https://doi.org/10.3892/ijo.2016.3363
  • Pages: 1541-1552
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Abstract

The metastasis-associated phosphatase of regenerating liver-3 (PRL-3) plays multiple roles in progression of various human cancers; however, significance of its role during development has not been addressed. Here we cloned and characterized the expression pattern of zebrafish prl-3 transcript and showed that it is ubiquitiously expressed in the first 24 h of development with both maternal and zygotic expressions. The transcripts become progressively restricted to the notochord, vessels and the intestine by 96 h post-fertilization. Notably, overexpression of zebrafish Prl-3 (zPrl-3) and human PRL-3 induces notochord malformation in zebrafish. This phenotype resembles chordoma and is confirmed by associated misexpression of notochord-specific markers. Clinical significance of the PRL-3 in chordoma is strongly suggested by detection of PRL-3 antigen in clinical chordoma specimens. Collectively, our results uncovered that aberrant overexpression of PRL-3 could initiate chordoma in early development and suggest the use of PRL-3 could be used as a predictor and a therapeutic target for chordoma.

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April 2016
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Copy and paste a formatted citation
APA
Li, L., Shi, H., Zhang, M., Guo, X., Tong, F., Zhang, W. ... Yang, S. (2016). Upregulation of metastasis-associated PRL-3 initiates chordoma in zebrafish. International Journal of Oncology, 48, 1541-1552. https://doi.org/10.3892/ijo.2016.3363
MLA
Li, L., Shi, H., Zhang, M., Guo, X., Tong, F., Zhang, W., Zhou, J., Wang, H., Yang, S."Upregulation of metastasis-associated PRL-3 initiates chordoma in zebrafish". International Journal of Oncology 48.4 (2016): 1541-1552.
Chicago
Li, L., Shi, H., Zhang, M., Guo, X., Tong, F., Zhang, W., Zhou, J., Wang, H., Yang, S."Upregulation of metastasis-associated PRL-3 initiates chordoma in zebrafish". International Journal of Oncology 48, no. 4 (2016): 1541-1552. https://doi.org/10.3892/ijo.2016.3363