αβ T-cell receptor bias in disease and therapy (Review)
- Authors:
- Chun-Yan Wang
- Pei-Fa Yu
- Xiao-Bing He
- Yong-Xiang Fang
- Wen-Yu Cheng
- Zhi-Zhong Jing
-
Affiliations: State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Public Health of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, P.R. China - Published online on: April 18, 2016 https://doi.org/10.3892/ijo.2016.3492
- Pages: 2247-2256
This article is mentioned in:
Abstract
 |
|
Casrouge A, Beaudoing E, Dalle S, Pannetier C, Kanellopoulos J and Kourilsky P: Size estimate of the alpha beta TCR repertoire of naive mouse splenocytes. J Immunol. 164:5782–5787. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Davis MM and Bjorkman PJ: T-cell antigen receptor genes and T-cell recognition. Nature. 334:395–402. 1988. View Article : Google Scholar : PubMed/NCBI | |
|
Jorgensen JL, Reay PA, Ehrich EW and Davis MM: Molecular components of T-cell recognition. Annu Rev Immunol. 10:835–873. 1992. View Article : Google Scholar : PubMed/NCBI | |
|
Treiner E, Duban L, Bahram S, Radosavljevic M, Wanner V, Tilloy F, Affaticati P, Gilfillan S and Lantz O: Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature. 422:164–169. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Le Bourhis L, Martin E, Péguillet I, Guihot A, Froux N, Coré M, Lévy E, Dusseaux M, Meyssonnier V, Premel V, et al: Antimicrobial activity of mucosal-associated invariant T cells. Nat Immunol. 11:701–708. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Van Rhijn I, Kasmar A, de Jong A, Gras S, Bhati M, Doorenspleet ME, de Vries N, Godfrey DI, Altman JD, de Jager W, et al: A conserved human T cell population targets mycobacterial antigens presented by CD1b. Nat Immunol. 14:706–713. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Beckman EM, Porcelli SA, Morita CT, Behar SM, Furlong ST and Brenner MB: Recognition of a lipid antigen by CD1-restricted αβ+ T cells. Nature. 372:691–694. 1994. View Article : Google Scholar : PubMed/NCBI | |
|
Latha TS, Reddy MC, Durbaka PV, Rachamallu A, Pallu R and Lomada D: γδ T Cell-mediated immune responses in disease and therapy. Front Immunol. 5:5712014. View Article : Google Scholar | |
|
Caccia N, Bruns GA, Kirsch IR, Hollis GF, Bertness V and Mak TW: T cell receptor alpha chain genes are located on chromosome 14 at 14q11-14q12 in humans. J Exp Med. 161:1255–1260. 1985. View Article : Google Scholar : PubMed/NCBI | |
|
Sewell AK: Why must T cells be cross-reactive? Nat Rev Immunol. 12:669–677. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Arstila TP, Casrouge A, Baron V, Even J, Kanellopoulos J and Kourilsky P: A direct estimate of the human alphabeta T cell receptor diversity. Science. 286:958–961. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Bentley GA, Boulot G, Karjalainen K and Mariuzza RA: Crystal structure of the beta chain of a T cell antigen receptor. Science. 267:1984–1987. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Fields BA, Ober B, Malchiodi EL, Lebedeva MI, Braden BC, Ysern X, Kim JK, Shao X, Ward ES and Mariuzza RA: Crystal structure of the V α domain of a T cell antigen receptor. Science. 270:1821–1824. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Pannetier C, Cochet M, Darche S, Casrouge A, Zöller M and Kourilsky P: The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments. Proc Natl Acad Sci USA. 90:4319–4323. 1993. View Article : Google Scholar : PubMed/NCBI | |
|
Rock EP, Sibbald PR, Davis MM and Chien YH: CDR3 length in antigen-specific immune receptors. J Exp Med. 179:323–328. 1994. View Article : Google Scholar : PubMed/NCBI | |
|
Turner SJ, Doherty PC, McCluskey J and Rossjohn J: Structural determinants of T-cell receptor bias in immunity. Nat Rev Immunol. 6:883–894. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Woodsworth DJ, Castellarin M and Holt RA: Sequence analysis of T-cell repertoires in health and disease. Genome Med. 5:982013. View Article : Google Scholar : PubMed/NCBI | |
|
Imai N, Ikeda H, Tawara I and Shiku H: Tumor progression inhibits the induction of multifunctionality in adoptively transferred tumor-specific CD8+ T cells. Eur J Immunol. 39:241–253. 2009. View Article : Google Scholar | |
|
Rezvany MR, Jeddi-Tehrani M, Osterborg A, Kimby E, Wigzell H and Mellstedt H: Oligoclonal TCRBV gene usage in B-cell chronic lymphocytic leukemia: Major perturbations are preferentially seen within the CD4 T-cell subset. Blood. 94:1063–1069. 1999.PubMed/NCBI | |
|
Lake DF, Salgaller ML, van der Bruggen P, Bernstein RM and Marchalonis JJ: Construction and binding analysis of recombinant single-chain TCR derived from tumor-infiltrating lymphocytes and a cytotoxic T lymphocyte clone directed against MAGE-1. Int Immunol. 11:745–751. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Farina C, van der Bruggen P, Boël P, Parmiani G, Sensi M and Moretta L: Conserved TCR usage by HLA-Cw* 1601-restricted T cell clones recognizing melanoma antigens. Int Immunol. 8:1463–1466. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Boon T, Gajewski TF and Coulie PG: From defined human tumor antigens to effective immunization? Immunol Today. 16:334–336. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Salvi S, Segalla F, Rao S, Arienti F, Sartori M, Bratina G, Caronni E, Anichini A, Clemente C, Parmiani G, et al: Overexpression of the T-cell receptor beta-chain variable region TCRBV14 in HLA-A2-matched primary human melanomas. Cancer Res. 55:3374–3379. 1995.PubMed/NCBI | |
|
Puisieux I, Even J, Pannetier C, Jotereau F, Favrot M and Kourilsky P: Oligoclonality of tumor-infiltrating lymphocytes from human melanomas. J Immunol. 153:2807–2818. 1994.PubMed/NCBI | |
|
Farace F, Orlanducci F, Dietrich PY, Gaudin C, Angevin E, Courtier MH, Bayle C, Hercend T and Triebel F: T cell repertoire in patients with B chronic lymphocytic leukemia. Evidence for multiple in vivo T cell clonal expansions. J Immunol. 153:4281–4290. 1994.PubMed/NCBI | |
|
Brown RD, Yuen E, Nelson M, Gibson J and Joshua D: The prognostic significance of T cell receptor beta gene rearrangements and idiotype-reactive T cells in multiple myeloma. Leukemia. 11:1312–1317. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Rezvany MR, Jeddi-Tehrani M, Wigzell H, Österborg A and Mellstedt H: Leukemia-associated monoclonal and oligoclonal TCR-BV use in patients with B-cell chronic lymphocytic leukemia. Blood. 101:1063–1070. 2003. View Article : Google Scholar | |
|
Li H, Ma X, Moskovits T, Inghirami G and Tsiagbe VK: Identification of oligoclonal CD4 T cells in diffuse large B cell lymphomas. Clin Immunol. 107:160–169. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Tan H, Ye J, Luo X, Chen S, Yin Q, Yang L and Li Y: Clonal expanded TRA and TRB subfamily T cells in peripheral blood from patients with diffuse large B-cell lymphoma. Hematology. 15:81–87. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou J, Ma R, Luo R, Sun Y, He X, Sun W, Tang W and Yao X: Primary exploration of CDR3 spectratyping and molecular features of TCR β chain in the peripheral blood and tissue of patients with colorectal carcinoma. Cancer Epidemiol. 34:733–740. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Baier PK, Wimmenauer S, Hirsch T, von Specht BU, von Kleist S, Keller H and Farthmann EH: Analysis of the T cell receptor variability of tumor-infiltrating lymphocytes in colorectal carcinomas. Tumor Biol. 19:205–212. 1998. View Article : Google Scholar | |
|
McHeyzer-Williams LJ, Panus JF, Mikszta JA and McHeyzer-Williams MG: Evolution of antigen-specific T cell receptors in vivo: Preimmune and antigen-driven selection of preferred complementarity-determining region 3 (CDR3) motifs. J Exp Med. 189:1823–1838. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Busch DH and Pamer EG: T cell affinity maturation by selective expansion during infection. J Exp Med. 189:701–710. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Zhong W and Reinherz EL: In vivo selection of a TCR Vbeta repertoire directed against an immunodominant influenza virus CTL epitope. Int Immunol. 16:1549–1559. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Argaet VP, Schmidt CW, Burrows SR, Silins SL, Kurilla MG, Doolan DL, Suhrbier A, Moss DJ, Kieff E, Sculley TB, et al: Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus. J Exp Med. 180:2335–2340. 1994. View Article : Google Scholar : PubMed/NCBI | |
|
Pantaleo G, Demarest JF, Soudeyns H, Graziosi C, Denis F, Adelsberger JW, Borrow P, Saag MS, Shaw GM, Sekaly RP, et al: Major expansion of CD8+ T cells with a predominant V β usage during the primary immune response to HIV. Nature. 370:463–467. 1994. View Article : Google Scholar : PubMed/NCBI | |
|
Price DA, West SM, Betts MR, Ruff LE, Brenchley JM, Ambrozak DR, Edghill-Smith Y, Kuroda MJ, Bogdan D, Kunstman K, et al: T cell receptor recognition motifs govern immune escape patterns in acute SIV infection. Immunity. 21:793–803. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Trautmann L, Rimbert M, Echasserieau K, Saulquin X, Neveu B, Dechanet J, Cerundolo V and Bonneville M: Selection of T cell clones expressing high-affinity public TCRs within Human cytomegalovirus-specific CD8 T cell responses. J Immunol. 175:6123–6132. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Gillespie GMA, Stewart-Jones G, Rengasamy J, Beattie T, Bwayo JJ, Plummer FA, Kaul R, McMichael AJ, Easterbrook P, Dong T, et al: Strong TCR conservation and altered T cell cross-reactivity characterize a B*57-restricted immune response in HIV-1 infection. J Immunol. 177:3893–3902. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Price DA, Brenchley JM, Ruff LE, Betts MR, Hill BJ, Roederer M, Koup RA, Migueles SA, Gostick E, Wooldridge L, et al: Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses. J Exp Med. 202:1349–1361. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Miconnet I, Marrau A, Farina A, Taffé P, Vigano S, Harari A and Pantaleo G: Large TCR diversity of virus-specific CD8 T cells provides the mechanistic basis for massive TCR renewal after antigen exposure. J Immunol. 186:7039–7049. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Gras S, Kjer-Nielsen L, Burrows SR, McCluskey J and Rossjohn J: T-cell receptor bias and immunity. Curr Opin Immunol. 20:119–125. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Callan MF, Annels N, Steven N, Tan L, Wilson J, McMichael AJ and Rickinson AB: T cell selection during the evolution of CD8+ T cell memory in vivo. Eur J Immunol. 28:4382–4390. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Miles JJ, Borg NA, Brennan RM, Tynan FE, Kjer-Nielsen L, Silins SL, Bell MJ, Burrows JM, McCluskey J, Rossjohn J, et al: TCR α genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope. J Immunol. 177:6804–6814. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Tynan FE, Burrows SR, Buckle AM, Clements CS, Borg NA, Miles JJ, Beddoe T, Whisstock JC, Wilce MC, Silins SL, et al: T cell receptor recognition of a ‘super-bulged’ major histocompatibility complex class I-bound peptide. Nat Immunol. 6:1114–1122. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Dolton G, Tungatt K, Lloyd A, Bianchi V, Theaker SM, Trimby A, Holland CJ, Donia M, Godkin AJ, Cole DK, et al: More tricks with tetramers: A practical guide to staining T cells with peptide-MHC multimers. Immunology. 146:11–22. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Wilson JD, Ogg GS, Allen RL, Goulder PJ, Kelleher A, Sewell AK, O'Callaghan CA, Rowland-Jones SL, Callan MF and McMichael AJ: Oligoclonal expansions of CD8+ T cells in chronic HIV infection are antigen specific. J Exp Med. 188:785–790. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Moss PA, Moots RJ, Rosenberg WM, Rowland-Jones SJ, Bodmer HC, McMichael AJ and Bell JI: Extensive conservation of alpha and beta chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide. Proc Natl Acad Sci USA. 88:8987–8990. 1991. View Article : Google Scholar : PubMed/NCBI | |
|
Boehme CC, Nicol MP, Nabeta P, Michael JS, Gotuzzo E, Tahirli R, Gler MT, Blakemore R, Worodria W, Gray C, et al: Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: A multicentre implementation study. Lancet. 377:1495–1505. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Geiger R, Duhen T, Lanzavecchia A and Sallusto F: Human naive and memory CD4+ T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells. J Exp Med. 206:1525–1534. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Tully G, Kortsik C, Höhn H, Zehbe I, Hitzler WE, Neukirch C, Freitag K, Kayser K and Maeurer MJ: Highly focused T cell responses in latent human pulmonary Mycobacterium tuberculosis infection. J Immunol. 174:2174–2184. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Jacobsen M, Detjen AK, Mueller H, Gutschmidt A, Leitner S, Wahn U, Magdorf K and Kaufmann SHE: Clonal expansion of CD8+ effector T cells in childhood tuberculosis. J Immunol. 179:1331–1339. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Flynn JL and Chan J: Immunology of tuberculosis. Annu Rev Immunol. 19:93–129. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Luo W, Zhang XB, Huang YT, Hao PP, Jiang ZM, Wen Q, Zhou MQ, Jin Q and Ma L: Development of genetically engineered CD4+ and CD8+ T cells expressing TCRs specific for a M. tuberculosis 38-kDa antigen. J Mol Med Berl. 89:903–913. 2011. View Article : Google Scholar | |
|
Luo W, Su J, Zhang XB, Yang Z, Zhou MQ, Jiang ZM, Hao PP, Liu SD, Wen Q, Jin Q, et al: Limited T cell receptor repertoire diversity in tuberculosis patients correlates with clinical severity. PLoS One. 7:e481172012. View Article : Google Scholar : PubMed/NCBI | |
|
Boubou MI, Collette A, Voegtlé D, Mazier D, Cazenave PA and Pied S: T cell response in malaria pathogenesis: Selective increase in T cells carrying the TCR Vβ8 during experimental cerebral malaria. Int Immunol. 11:1553–1562. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Li Y: Research and application of T-cell receptor. People's Medical Publishing House; Beijing: pp. 1322009, (in Chinese). | |
|
Murata H, Matsumura R, Koyama A, Sugiyama T, Sueishi M, Shibuya K, Tsutsumi A and Sumida T: T cell receptor repertoire of T cells in the kidneys of patients with lupus nephritis. Arthritis Rheum. 46:2141–2147. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Furukawa F, Tokura Y, Matsushita K, Iwasaki-Inuzuka K, Onagi-Suzuki K, Yagi H, Wakita H and Takigawa M: Selective expansions of T cells expressing Vβ8 and Vβ13 in skin lesions of patients with chronic cutaneous lupus erythematosus. J Dermatol. 23:670–676. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Mato T, Masuko K, Misaki Y, Hirose N, Ito K, Takemoto Y, Izawa K, Yamamori S, Kato T, Nishioka K, et al: Correlation of clonal T cell expansion with disease activity in systemic lupus erythematosus. Int Immunol. 9:547–554. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Desai-Mehta A, Mao C, Rajagopalan S, Robinson T and Datta SK: Structure and specificity of T cell receptors expressed by potentially pathogenic anti-DNA autoantibody-inducing T cells in human lupus. J Clin Invest. 95:531–541. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Luo W, Ma L, Wen Q, Wang N, Zhou MQ and Wang XN: Analysis of the interindividual conservation of T cell receptor α- and β-chain variable regions gene in the peripheral blood of patients with systemic lupus erythematosus. Clin Exp Immunol. 154:316–324. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Codina-Busqueta E, Scholz E, Muñoz-Torres PM, Roura-Mir C, Costa M, Xufré C, Planas R, Vives-Pi M, Jaraquemada D and Martí M: TCR bias of in vivo expanded T cells in pancreatic islets and spleen at the onset in human type 1 diabetes. J Immunol. 186:3787–3797. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou J, Kong C, Jia Y, Wang L, Jin C and Wang X: The skewness of alpha beta T cell receptors in peripheral blood of the patients with type 1 diabetes. Exp Clin Endocrinol Diabetes. 124:1–4. 2016. | |
|
Kim JY, Balamurugan A, Azari K, Hofmann C, Ng HL, Reed EF, McDiarmid S and Yang OO: Clonal CD8+ T cell persistence and variable gene usage bias in a human transplanted hand. PLoS One. 10:e01362352015. View Article : Google Scholar | |
|
Luo W, Liao WJ, Huang YT, Shi M, Zhang Y, Wen Q, Zhou MQ and Ma L: Normalization of T cell receptor repertoire diversity in patients with advanced colorectal cancer who responded to chemotherapy. Cancer Sci. 102:706–712. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Luo W, Liao WJ, Ma L, Huang YT, Shi M, Wen Q and Wang XN: Dynamic monitoring the TCR CDR3 spectratypes in patients with metastatic CRC treated with a combination of bevacizumab, irinotecan, fluorouracil, and leucovorin. Cancer Immunol Immunother. 59:247–256. 2010. View Article : Google Scholar | |
|
Yu AL, Gilman AL, Ozkaynak MF, London WB, Kreissman SG, Chen HX, Smith M, Anderson B, Villablanca JG, Matthay KK, et al; Children's Oncology Group. Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma. N Engl J Med. 363:1324–1334. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Hank JA, Robinson RR, Surfus J, Mueller BM, Reisfeld RA, Cheung NK and Sondel PM: Augmentation of antibody dependent cell mediated cytotoxicity following in vivo therapy with recombinant interleukin 2. Cancer Res. 50:5234–5239. 1990.PubMed/NCBI | |
|
Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, Hwu P, Drake CG, Camacho LH, Kauh J, Odunsi K, et al: Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 366:2455–2465. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, Powderly JD, Carvajal RD, Sosman JA, Atkins MB, et al: Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 366:2443–2454. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Wolchok JD, Kluger H, Callahan MK, Postow MA, Rizvi NA, Lesokhin AM, Segal NH, Ariyan CE, Gordon RA, Reed K, et al: Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med. 369:122–133. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Bowman L, Grossmann M, Rill D, Brown M, Zhong WY, Alexander B, Leimig T, Coustan-Smith E, Campana D, Jenkins J, et al: IL-2 adenovector-transduced autologous tumor cells induce antitumor immune responses in patients with neuroblastoma. Blood. 92:1941–1949. 1998.PubMed/NCBI | |
|
Brenner MK, Heslop H, Krance R, Horowitz M, Strother D, Nuchtern J, Grilley B, Martingano E and Cooper K: Phase I study of chemokine and cytokine gene-modified autologous neuroblastoma cells for treatment of relapsed/refractory neuroblastoma using an adenoviral vector. Hum Gene Ther. 11:1477–1488. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Pule MA, Savoldo B, Myers GD, Rossig C, Russell HV, Dotti G, Huls MH, Liu E, Gee AP, Mei Z, et al: Virus-specific T cells engineered to coexpress tumor-specific receptors: Persistence and antitumor activity in individuals with neuroblastoma. Nat Med. 14:1264–1270. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Louis CU, Savoldo B, Dotti G, Pule M, Yvon E, Myers GD, Rossig C, Russell HV, Diouf O, Liu E, et al: Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma. Blood. 118:6050–6056. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Park JR, Digiusto DL, Slovak M, Wright C, Naranjo A, Wagner J, Meechoovet HB, Bautista C, Chang WC, Ostberg JR, et al: Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma. Mol Ther. 15:825–833. 2007.PubMed/NCBI | |
|
Cheung NKV, Cheung IY, Kushner BH, Ostrovnaya I, Chamberlain E, Kramer K and Modak S: Murine anti-GD2 monoclonal antibody 3F8 combined with granulocyte-macrophage colony-stimulating factor and 13-cis-retinoic acid in high-risk patients with stage 4 neuroblastoma in first remission. J Clin Oncol. 30:3264–3270. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Mackall CL, Fleisher TA, Brown MR, Magrath IT, Shad AT, Horowitz ME, Wexler LH, Adde MA, McClure LL and Gress RE: Lymphocyte depletion during treatment with intensive chemotherapy for cancer. Blood. 84:2221–2228. 1994.PubMed/NCBI | |
|
June CH, Riddell SR and Schumacher TN: Adoptive cellular therapy: A race to the finish line. Sci Transl Med. 7:280ps72015. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang M, Ma Z, Selliah N, Weiss G, Genin A, Finkel TH and Cron RQ: The impact of Nucleofection® on the activation state of primary human CD4 T cells. J Immunol Methods. 408:123–131. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Clay TM, Custer MC, Sachs J, Hwu P, Rosenberg SA and Nishimura MI: Efficient transfer of a tumor antigen-reactive TCR to human peripheral blood lymphocytes confers anti-tumor reactivity. J Immunol. 163:507–513. 1999.PubMed/NCBI | |
|
Duval L, Schmidt H, Kaltoft K, Fode K, Jensen JJ, Sorensen SM, Nishimura MI and von der Maase H: Adoptive transfer of allogeneic cytotoxic T lymphocytes equipped with a HLA-A2 restricted MART-1 T-cell receptor: a phase I trial in metastatic melanoma. Clin Cancer Res. 12:1229–1236. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Tang H, Qiao J and Fu YX: Immunotherapy and tumor microenvironment. Cancer Lett. 370:85–90. 2016. View Article : Google Scholar | |
|
Cohen CJ, Zhao Y, Zheng Z, Rosenberg SA and Morgan RA: Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability. Cancer Res. 66:8878–8886. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Kuball J, Dossett ML, Wolfl M, Ho WY, Voss RH, Fowler C and Greenberg PD: Facilitating matched pairing and expression of TCR chains introduced into human T cells. Blood. 109:2331–2338. 2007. View Article : Google Scholar | |
|
Bendle GM, Linnemann C, Hooijkaas AI, Bies L, de Witte MA, Jorritsma A, Kaiser ADM, Pouw N, Debets R, Kieback E, et al: Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy. Nat Med. 16:565–570. 1p5702010. View Article : Google Scholar : PubMed/NCBI | |
|
Lan P, Wang L, Diouf B, Eguchi H, Su H, Bronson R, Sachs DH, Sykes M and Yang YG: Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism. Blood. 103:3964–3969. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Lan P, Tonomura N, Shimizu A, Wang S and Yang YG: Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation. Blood. 108:487–492. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Tonomura N, Habiro K, Shimizu A, Sykes M and Yang YG: Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model. Blood. 111:4293–4296. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Hu Z, Xia J, Fan W, Wargo J and Yang YG: Human melanoma immunotherapy using tumor antigen-specific T cells generated in humanized mice. Oncotarget. Jan 27–2016.(Epub ahead of print). | |
|
Harris DT, Kranz DM and Adoptive T: Cell therapies: A comparison of T cell receptors and chimeric antigen receptors. Trends Pharmacol Sci. 37:220–230. 2015. View Article : Google Scholar | |
|
Heczey A and Louis CU: Advances in chimeric antigen receptor immunotherapy for neuroblastoma. Discov Med. 16:287–294. 2013.PubMed/NCBI | |
|
Maus MV, Grupp SA, Porter DL and June CH: Antibody-modified T cells: CARs take the front seat for hematologic malignancies. Blood. 123:2625–2635. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Alrifai D, Sarker D and Maher J: Prospects for adoptive immunotherapy of pancreatic cancer using chimeric antigen receptor-engineered T-cells. Immunopharm Immunot. 38:50–60. 2016. View Article : Google Scholar | |
|
Parkhurst MR, Yang JC, Langan RC, Dudley ME, Nathan DAN, Feldman SA, Davis JL, Morgan RA, Merino MJ, Sherry RM, et al: T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis. Mol Ther. 19:620–626. 2011. View Article : Google Scholar : | |
|
Kaldor JM, Day NE, Pettersson F, Clarke EA, Pedersen D, Mehnert W, Bell J, Høst H, Prior P, Karjalainen S, et al: Leukemia following chemotherapy for ovarian cancer. N Engl J Med. 322:1–6. 1990. View Article : Google Scholar : PubMed/NCBI |
