TGF-BETA-INDUCED APOPTOSIS OF TRANSFORMED FIBROBLASTS BY NORMAL FIBROBLASTS - INDEPENDENCE OF CELL-TO-CELL CONTACT AND DEPENDENCE ON REACTIVE OXYGEN SPECIES

  • Authors:
    • JM JURGENSMEIER
    • P HOFLER
    • G BAUER
  • View Affiliations

  • Published online on: September 1, 1994     https://doi.org/10.3892/ijo.5.3.525
  • Pages: 525-531
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Abstract

We studied the elimination of transformed fibroblasts induced by TGF-beta-treated normal fibroblasts. Kinetic experiments revealed two steps: First, the elimination process is induced in the normal cells by TGF-beta and later, the apoptosis of transformed cells is mediated by a short-lived effector different from TGF-beta and TNF. The killing of the transformed cells is directly observable as a cytopathic effect. It does not depend on cell-to-cell contact between normal and transformed cells. Reactive oxygen species (ROS) play an important role in the elimination process but are not the apoptosis-inducing signal transmitted from TGF-beta-treated normal cells.

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September 1994
Volume 5 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
JURGENSMEIER J, HOFLER P and BAUER G: TGF-BETA-INDUCED APOPTOSIS OF TRANSFORMED FIBROBLASTS BY NORMAL FIBROBLASTS - INDEPENDENCE OF CELL-TO-CELL CONTACT AND DEPENDENCE ON REACTIVE OXYGEN SPECIES. Int J Oncol 5: 525-531, 1994.
APA
JURGENSMEIER, J., HOFLER, P., & BAUER, G. (1994). TGF-BETA-INDUCED APOPTOSIS OF TRANSFORMED FIBROBLASTS BY NORMAL FIBROBLASTS - INDEPENDENCE OF CELL-TO-CELL CONTACT AND DEPENDENCE ON REACTIVE OXYGEN SPECIES. International Journal of Oncology, 5, 525-531. https://doi.org/10.3892/ijo.5.3.525
MLA
JURGENSMEIER, J., HOFLER, P., BAUER, G."TGF-BETA-INDUCED APOPTOSIS OF TRANSFORMED FIBROBLASTS BY NORMAL FIBROBLASTS - INDEPENDENCE OF CELL-TO-CELL CONTACT AND DEPENDENCE ON REACTIVE OXYGEN SPECIES". International Journal of Oncology 5.3 (1994): 525-531.
Chicago
JURGENSMEIER, J., HOFLER, P., BAUER, G."TGF-BETA-INDUCED APOPTOSIS OF TRANSFORMED FIBROBLASTS BY NORMAL FIBROBLASTS - INDEPENDENCE OF CELL-TO-CELL CONTACT AND DEPENDENCE ON REACTIVE OXYGEN SPECIES". International Journal of Oncology 5, no. 3 (1994): 525-531. https://doi.org/10.3892/ijo.5.3.525