Open Access

Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells

  • Authors:
    • Xue Wang
    • Jiaojiao Deng
    • Jinxia Yuan
    • Xin Tang
    • Yuelong Wang
    • Haifeng Chen
    • Yi Liu
    • Liangxue Zhou
  • View Affiliations

  • Published online on: June 8, 2017     https://doi.org/10.3892/ijo.2017.4037
  • Pages: 467-477
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glioblastoma is the most common brain cancer in adults. It represents one of the top ten malignant tumors with an average survival time of nine months despite treatments with surgery, radiotherapy and chemotherapy. Curcumin is a phytochemical turmeric isolated from root of the Curcuma longa plant. Accumulating evidence have proved that curcumin targets numerous cancer signaling pathways. The E3 ubiquitin ligase NEDD4, neural precursor cell expressed developmentally downregulated protein 4, is frequently overexpressed in various cancers. However, whether curcumin regulates NEDD4 expression has not been described in human cancers. Therefore, in this study, we explored the roles of NEDD4 in glioma cell proliferation, apoptosis and mobility. We further investigated whether curcumin exerts its antitumor activities via suppressing NEDD4 expression. We found that curcumin reduced the expression of NEDD4 and Notch1 and pAKT, leading to glioma cell growth inhibition, apoptosis, and suppression of migration and invasion. Moreover, deletion of NEDD4 expression enhanced the sensitivity of glioma cells to curcumin treatment. Thus, inactivation of NEDD4 by curcumin could be a promising approach for therapeutic intervention.
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August-2017
Volume 51 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Wang X, Deng J, Yuan J, Tang X, Wang Y, Chen H, Liu Y and Zhou L: Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells. Int J Oncol 51: 467-477, 2017
APA
Wang, X., Deng, J., Yuan, J., Tang, X., Wang, Y., Chen, H. ... Zhou, L. (2017). Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells. International Journal of Oncology, 51, 467-477. https://doi.org/10.3892/ijo.2017.4037
MLA
Wang, X., Deng, J., Yuan, J., Tang, X., Wang, Y., Chen, H., Liu, Y., Zhou, L."Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells". International Journal of Oncology 51.2 (2017): 467-477.
Chicago
Wang, X., Deng, J., Yuan, J., Tang, X., Wang, Y., Chen, H., Liu, Y., Zhou, L."Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells". International Journal of Oncology 51, no. 2 (2017): 467-477. https://doi.org/10.3892/ijo.2017.4037