Antitumoral effect of arsenic compound, sodium metaarsenite (KML001), on multiple myeloma cells

  • Authors:
    • Seo Ju Kim
    • Eun Shil Kim
    • Sujong Kim
    • Jieun Uhm
    • Young Woong Won
    • Byeong Bae Park
    • Jung Hye Choi
    • Young Yiul Lee
  • View Affiliations

  • Published online on: October 16, 2017     https://doi.org/10.3892/ijo.2017.4161
  • Pages:1739-1746
0

Abstract

KML001 (sodium metaarsenite;NaAs2O3) is known to have antitumor activity against a variety of cancers. In this study, we examined its effect on multiple myeloma (MM). KML001 reduced the growth of all MM cell lines examined with an IC50 of 5x10‑8 M. Exposure to KML001 (5x10‑8 M) decreased levels of cyclins A/B1/D1/E1, CDK2/4/6 in U266 cells and increased the p21 and p27 levels. Furthermore, p21 became bound to CDK2/4/6, resulting in a reduction of CDK2/4/6 kinase activity. The cleaved forms of Bcl-2, and caspases‑3, ‑8 and ‑9 were detected, and the anti-apoptotic molecule, Bax, also increased. Activation of STAT1/3, NF-κB (p65 and p50 subunits), pAKT and pERK decreased, and p‑PTEN increased. There was also a significant reduction of hTERT at 12 h and upregulation of γ-H2AX and CHK1/2 molecules at 24 h. Thus, KML001 appears to have antitumor activity against MM by inhibiting various oncogenic signaling pathways. It may be useful for treating MM.

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December 2017
Volume 51 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

2016 Impact Factor: 3.079
Ranked #33/217 Oncology
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APA
Kim, S.J., Kim, E.S., Kim, S., Uhm, J., Won, Y.W., Park, B.B. ... Lee, Y.Y. (2017). Antitumoral effect of arsenic compound, sodium metaarsenite (KML001), on multiple myeloma cells. International Journal of Oncology, 51, 1739-1746. https://doi.org/10.3892/ijo.2017.4161
MLA
Kim, S. J., Kim, E. S., Kim, S., Uhm, J., Won, Y. W., Park, B. B., Choi, J. H., Lee, Y. Y."Antitumoral effect of arsenic compound, sodium metaarsenite (KML001), on multiple myeloma cells". International Journal of Oncology 51.6 (2017): 1739-1746.
Chicago
Kim, S. J., Kim, E. S., Kim, S., Uhm, J., Won, Y. W., Park, B. B., Choi, J. H., Lee, Y. Y."Antitumoral effect of arsenic compound, sodium metaarsenite (KML001), on multiple myeloma cells". International Journal of Oncology 51, no. 6 (2017): 1739-1746. https://doi.org/10.3892/ijo.2017.4161