Molecular mechanism and targeted therapy of Hsp90 involved in lung cancer: New discoveries and developments (Review)

  • Authors:
    • Biaoxue Rong
    • Shuanying Yang
  • View Affiliations

  • Published online on: November 29, 2017     https://doi.org/10.3892/ijo.2017.4214
  • Pages:321-336
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Abstract

The exploration of the molecular mechanisms and signaling pathways on lung cancer is very important for developing new strategies of diagnosis and treatment to this disease, such as finding valuable lung cancer markers and molecularly targeted therapies. Previously, a number of studies disclose that heat shock protein 90 (Hsp90) is upregulated in cancer cells, tissues and serum of lung cancer patients, and its upregulation intimately correlates with the occurrence, development and outcome of lung cancer. On the contrary, inhibition of Hsp90 can suppress cell proliferation, motility and metastasis of lung cancer and promote apoptosis of lung cancer cells via complex signaling pathways. In addition, a series of Hsp90 inhibitors have been investigated as effective molecular targeted therapy tactics fighting against lung cancer. This review, systematically summarizes the role of Hsp90 in lung cancer, the molecular mechanisms and development of anti-Hsp90 treatment in lung cancer.

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February 2018
Volume 52 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Rong, B., & Rong, B. (2018). Molecular mechanism and targeted therapy of Hsp90 involved in lung cancer: New discoveries and developments (Review). International Journal of Oncology, 52, 321-336. https://doi.org/10.3892/ijo.2017.4214
MLA
Rong, B., Yang, S."Molecular mechanism and targeted therapy of Hsp90 involved in lung cancer: New discoveries and developments (Review)". International Journal of Oncology 52.2 (2018): 321-336.
Chicago
Rong, B., Yang, S."Molecular mechanism and targeted therapy of Hsp90 involved in lung cancer: New discoveries and developments (Review)". International Journal of Oncology 52, no. 2 (2018): 321-336. https://doi.org/10.3892/ijo.2017.4214