Anticancer activity of the supercritical extract of Brazilian green propolis and its active component, artepillin C: Bioinformatics and experimental analyses of its mechanisms of action

  • Authors:
    • Priyanshu Bhargava
    • Abhinav Grover
    • Nupur Nigam
    • Ashish Kaul
    • Motomichi Doi
    • Yoshiyuki Ishida
    • Hanzo Kakuta
    • Sunil C. Kaul
    • Keiji Terao
    • Renu Wadhwa
  • View Affiliations

  • Published online on: January 22, 2018     https://doi.org/10.3892/ijo.2018.4249
  • Pages:925-932
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Abstract

Propolis, a resinous substance collected by honeybees by mixing their saliva with plant sources, including tree bark and leaves and then mixed with secreted beeswax, possesses a variety of bioactivities. Whereas caffeic acid phenethyl ester (CAPE) has been recognized as a major bioactive ingredient in New Zealand propolis, Brazilian green propolis, on the other hand, possesses artepillin C (ARC). In this study, we report that, similar to CAPE, ARC docks into and abrogates mortalin-p53 complexes, causing the activation of p53 and the growth arrest of cancer cells. Cell viability assays using ARC and green propolis-supercritical extract (GPSE) revealed higher cytotoxicity in the latter, supported by nuclear translocation and the activation of p53. Furthermore, in vivo tumor suppression assays using nude mice, we found that GPSE and its conjugate with γ cyclodextrin (γCD) possessed more potent anticancer activity than purified ARC. GPSE‑γCD may thus be recommended as a natural, effective and economic anticancer amalgam.

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March 2018
Volume 52 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Bhargava, P., Grover, A., Nigam, N., Kaul, A., Doi, M., Ishida, Y. ... Wadhwa, R. (2018). Anticancer activity of the supercritical extract of Brazilian green propolis and its active component, artepillin C: Bioinformatics and experimental analyses of its mechanisms of action. International Journal of Oncology, 52, 925-932. https://doi.org/10.3892/ijo.2018.4249
MLA
Bhargava, P., Grover, A., Nigam, N., Kaul, A., Doi, M., Ishida, Y., Kakuta, H., Kaul, S. C., Terao, K., Wadhwa, R."Anticancer activity of the supercritical extract of Brazilian green propolis and its active component, artepillin C: Bioinformatics and experimental analyses of its mechanisms of action". International Journal of Oncology 52.3 (2018): 925-932.
Chicago
Bhargava, P., Grover, A., Nigam, N., Kaul, A., Doi, M., Ishida, Y., Kakuta, H., Kaul, S. C., Terao, K., Wadhwa, R."Anticancer activity of the supercritical extract of Brazilian green propolis and its active component, artepillin C: Bioinformatics and experimental analyses of its mechanisms of action". International Journal of Oncology 52, no. 3 (2018): 925-932. https://doi.org/10.3892/ijo.2018.4249