Open Access

Safe administration of bevacizumab combination chemotherapy for the patients with recurrent cervical cancer after pelvic radiotherapy: Two case reports

  • Authors:
    • Tadahiro Shoji
    • Ryosuke Takeshita
    • Rika Mukaida
    • Eriko Takatori
    • Takayuki Nagasawa
    • Hideo Omi
    • Toru Sugiyama
  • View Affiliations

  • Published online on: June 4, 2018     https://doi.org/10.3892/mco.2018.1642
  • Pages: 173-177
  • Copyright: © Shoji et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In Japan, bevacizumab has not been proven either effective or safe for the treatment of recurrent cervical cancer. The present study reported two cases in which bevacizumab combination chemotherapy was safely administered for recurrent cervical cancer following pelvic radiotherapy. Case 1 was a 62-year-old woman with stage IIIB squamous cell carcinoma of the cervix who had received whole pelvic external beam radiotherapy (WPEBRT) at a dose of 50.4 Gy and high dose rate intra-cavitary brachytherapy at a dose of 24 Gy to the pelvis one year earlier. For recurrent cervical cancer, chemotherapy with paclitaxel, carboplatin and bevacizumab was administered for six cycles. Case 2 was a 52-year-old woman with stage IIB squamous cell carcinoma of the cervix who had received WPEBRT at a dose of 50.4 Gy to the pelvis 11 years earlier. For lymph node and liver metastases, chemotherapy with paclitaxel, cisplatin, and bevacizumab was administered for six cycles. Although grade 2 proteinuria was observed in one of these patients, there were no intestinal perforation, fistula, hypertension, proteinuria or thrombosis events, which are the characteristic adverse reactions associated with bevacizumab. Hematotoxicity was also manageable. Regarding the antitumor effect, case 1 demonstrated a complete response, whereas case 2 resulted in stable disease.
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August-2018
Volume 9 Issue 2

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Shoji T, Takeshita R, Mukaida R, Takatori E, Nagasawa T, Omi H and Sugiyama T: Safe administration of bevacizumab combination chemotherapy for the patients with recurrent cervical cancer after pelvic radiotherapy: Two case reports. Mol Clin Oncol 9: 173-177, 2018
APA
Shoji, T., Takeshita, R., Mukaida, R., Takatori, E., Nagasawa, T., Omi, H., & Sugiyama, T. (2018). Safe administration of bevacizumab combination chemotherapy for the patients with recurrent cervical cancer after pelvic radiotherapy: Two case reports. Molecular and Clinical Oncology, 9, 173-177. https://doi.org/10.3892/mco.2018.1642
MLA
Shoji, T., Takeshita, R., Mukaida, R., Takatori, E., Nagasawa, T., Omi, H., Sugiyama, T."Safe administration of bevacizumab combination chemotherapy for the patients with recurrent cervical cancer after pelvic radiotherapy: Two case reports". Molecular and Clinical Oncology 9.2 (2018): 173-177.
Chicago
Shoji, T., Takeshita, R., Mukaida, R., Takatori, E., Nagasawa, T., Omi, H., Sugiyama, T."Safe administration of bevacizumab combination chemotherapy for the patients with recurrent cervical cancer after pelvic radiotherapy: Two case reports". Molecular and Clinical Oncology 9, no. 2 (2018): 173-177. https://doi.org/10.3892/mco.2018.1642