Oxidative stress marker 8-hydroxyguanosine is more highly expressed in prostate cancer than in benign prostatic hyperplasia

  • Authors:
    • Shinji Ohtake
    • Takashi Kawahara
    • Yukari Ishiguro
    • Teppei Takeshima
    • Shinnosuke Kuroda
    • Koji Izumi
    • Hiroshi Miyamoto
    • Hiroji Uemura
  • View Affiliations

  • Published online on: July 3, 2018     https://doi.org/10.3892/mco.2018.1665
  • Pages: 302-304
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Abstract

Oxidative stress is a primary cause of vascular endothelial damage. In the prostate, ischemia increases the levels of reactive oxygen species, growth factors and cytokines, and induces the development of angiogenesis, which results in cancer progression. The expression levels of an oxidative stress marker, 8-hydroxyguanosine (8-OHdG), were compared between prostate cancer and non-neoplastic prostate tissues. A prostate tissue microarray composed of 10 cases of prostatic adenocarcinoma and 70 cases of benign prostatic hyperplasia was immunohistochemically stained for 8-OHdG. All cases expressed 8-OHdG. The levels of 8-OHdG expression in prostatic cancer (30.0% moderate and 70.0% strong) were significantly higher than those in benign prostatic hyperplasia (71.4% moderate and 28.6% strong; (p<0.01). Notably, 8-OHdG is expressed more highly in prostate cancer tissues in comparison to benign prostate tissues.
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September-2018
Volume 9 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Ohtake S, Kawahara T, Ishiguro Y, Takeshima T, Kuroda S, Izumi K, Miyamoto H and Uemura H: Oxidative stress marker 8-hydroxyguanosine is more highly expressed in prostate cancer than in benign prostatic hyperplasia. Mol Clin Oncol 9: 302-304, 2018
APA
Ohtake, S., Kawahara, T., Ishiguro, Y., Takeshima, T., Kuroda, S., Izumi, K. ... Uemura, H. (2018). Oxidative stress marker 8-hydroxyguanosine is more highly expressed in prostate cancer than in benign prostatic hyperplasia. Molecular and Clinical Oncology, 9, 302-304. https://doi.org/10.3892/mco.2018.1665
MLA
Ohtake, S., Kawahara, T., Ishiguro, Y., Takeshima, T., Kuroda, S., Izumi, K., Miyamoto, H., Uemura, H."Oxidative stress marker 8-hydroxyguanosine is more highly expressed in prostate cancer than in benign prostatic hyperplasia". Molecular and Clinical Oncology 9.3 (2018): 302-304.
Chicago
Ohtake, S., Kawahara, T., Ishiguro, Y., Takeshima, T., Kuroda, S., Izumi, K., Miyamoto, H., Uemura, H."Oxidative stress marker 8-hydroxyguanosine is more highly expressed in prostate cancer than in benign prostatic hyperplasia". Molecular and Clinical Oncology 9, no. 3 (2018): 302-304. https://doi.org/10.3892/mco.2018.1665