Taurine supplementation reduces oxidative stress and protects the liver in an iron-overload murine model

Zhang,Zeyu; Liu,Dan; Yi,Bo; Liao,Zhangping; Tang,Lei; Yin,Dong; He,Ming

doi:10.3892/mmr.2014.2544

Taurine supplementation reduces oxidative stress and protects the liver in an iron-overload murine model

Authors:
- Zeyu Zhang
- Dan Liu
- Bo Yi
- Zhangping Liao
- Lei Tang
- Dong Yin
- Ming He
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Affiliations: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi 330047, P.R. China, Department of Pharmacology and Molecular Therapeutics, Nanchang University School of Pharmaceutical Science, Nanchang, Jiangxi 330006, P.R. China, Second Abdominal Surgery Department, Jiangxi Province Tumor Hospital, Nanchang, Jiangxi 330029, P.R. China, Jiangxi Provincial Key Laboratory of Molecular Medicine at the Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330006, P.R. China
Published online on: September 5, 2014 https://doi.org/10.3892/mmr.2014.2544
Pages: 2255-2262
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

We previously demonstrated that iron overload induces liver damage by causing the formation of reactive oxygen species (ROS). Taurine is a potent free radical scavenger that attenuates the damage caused by excessive oxygen free radicals. Therefore, the aim of the present study was to investigate whether taurine could reduce the hepatotoxicity of iron overload with regard to ROS production. Mice were intraperitoneally injected with iron 5 days/week for 13 weeks to achieve iron overload. It was found that iron overload resulted in liver dysfunction, increased apoptosis and elevated oxidative stress. Taurine supplementation increased liver taurine levels by 40% and led to improved liver function, as well as a reduction in apoptosis, ROS formation and mitochondrial swelling and an attenuation in the loss of the mitochondrial membrane potential. Treatment with taurine mediated a reduction in oxidative stress in iron‑overloaded mice, attenuated liver lipid peroxidation, elevated antioxidant enzyme activities and maintained reduced glutathione levels. These results indicate that taurine reduces iron‑induced hepatic oxidative stress, preserves liver function and inhibits hepatocyte apoptosis. Therefore, taurine may be a potential therapeutic drug to reduce liver damage caused by iron overload.

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