Open Access

Association of the angiopoietin-like protein 8 rs2278426 polymorphism and several environmental factors with serum lipid levels

  • Authors:
    • Tao Guo
    • Rui‑Xing Yin
    • Jian Wu
    • Quan‑Zhen Lin
    • Guang‑Yuan Shi
    • Shao‑Wen Shen
    • Jia‑Qi Sun
    • Hui Li
    • Wei‑Xiong Lin
    • De‑Zhai Yan
  • View Affiliations

  • Published online on: May 25, 2015     https://doi.org/10.3892/mmr.2015.3825
  • Pages: 3285-3296
  • Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study was performed to examine the association of the angiopoietin-like protein 8 (ANGPTL8) rs2278426 single nucleotide polymorphism (SNP) and several environmental factors with serum lipid profiles in the Mulao and Han populations. A total of 879 individuals of the Mulao ethnic group and 865 individuals of the Han Chinese ethnic group were included. The serum apolipoprotein (Apo) B level was higher, however the serum ApoA1 level was lower in the Mulao individuals than in the Han individuals (P<0.05 and P<0.001, respectively). The genotypic and allelic frequencies, and the association with the ANGPTL8 rs2278426 SNP were different between the Mulao and Han populations. The frequency of the A allele was 17.80% in Han individuals and 23.04% in Mulao individuals (P<0.001). The frequencies of GG, GA and AA genotypes were 68.79, 26.82 and 4.39% in the Han population, and 60.64, 32.65 and 6.71% in the Mulao population (P<0.005), respectively. A significant association between the SNP and serum lipid traits was only detected in Han females and not in Han males or in the Mulao population. The subjects with GA/AA genotypes had lower low‑density lipoprotein cholesterol (LDL‑C) and ApoB levels, and higher ApoA1 levels with a higher ApoA1/ApoB ratio than the subjects with the GG genotype in the Han population. Subgroup analyses revealed that the subjects with the GA/AA genotype had lower levels of total cholesterol, LDL‑C and ApoB, and a higher ApoA1/ApoB ratio than the subjects with the GG genotype in Han females (P<0.05‑P<0.001). Serum lipid parameters were also associated with several environmental factors, including dietary patterns, lifestyle, obesity, physical inactivity and hypertension, in the two ethnic groups (P<0.05‑0.001). These findings suggest that there may be an ethnic‑ and gender‑specific association of the rs2278426 SNP and serum lipid parameters.
View Figures
View References

Related Articles

Journal Cover

September-2015
Volume 12 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Guo T, Yin RX, Wu J, Lin QZ, Shi GY, Shen SW, Sun JQ, Li H, Lin WX, Yan DZ, Yan DZ, et al: Association of the angiopoietin-like protein 8 rs2278426 polymorphism and several environmental factors with serum lipid levels. Mol Med Rep 12: 3285-3296, 2015.
APA
Guo, T., Yin, R., Wu, J., Lin, Q., Shi, G., Shen, S. ... Yan, D. (2015). Association of the angiopoietin-like protein 8 rs2278426 polymorphism and several environmental factors with serum lipid levels. Molecular Medicine Reports, 12, 3285-3296. https://doi.org/10.3892/mmr.2015.3825
MLA
Guo, T., Yin, R., Wu, J., Lin, Q., Shi, G., Shen, S., Sun, J., Li, H., Lin, W., Yan, D."Association of the angiopoietin-like protein 8 rs2278426 polymorphism and several environmental factors with serum lipid levels". Molecular Medicine Reports 12.3 (2015): 3285-3296.
Chicago
Guo, T., Yin, R., Wu, J., Lin, Q., Shi, G., Shen, S., Sun, J., Li, H., Lin, W., Yan, D."Association of the angiopoietin-like protein 8 rs2278426 polymorphism and several environmental factors with serum lipid levels". Molecular Medicine Reports 12, no. 3 (2015): 3285-3296. https://doi.org/10.3892/mmr.2015.3825