MicroRNA-133a inhibits the malignant behavior of glioma via downregulation of matrix metallopeptidase 9

  • Authors:
    • Jianhong Wang
    • Jingcheng Li
    • Fuqiang Guo
    • Yong Yan
  • View Affiliations

  • Published online on: February 18, 2016     https://doi.org/10.3892/mmr.2016.4907
  • Pages: 3220-3226
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Abstract

MicroRNA (miR)-133a expression has been reported to be downregulated in numerous human malignancies. However, the expression levels and function of miR-133a have not yet been investigated in human glioma. In the present study, the expression of miR‑133a was analyzed by reverse transcription‑quantitative polymerase chain reaction. Following transfection of miR‑133a, cell proliferation, cell migration, cell invasion and luciferase assays, and western blot analysis were conducted in glioma cell lines. The present study demonstrated that miR‑133a was downregulated in human glioma tissues compared with in normal adjacent tissues. In addition, the results indicated that miR‑133a was likely to directly target matrix metallopeptidase 9 in glioma. These results suggest that miR-133a may be considered as a target for the treatment of human glioma.
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April-2016
Volume 13 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang J, Li J, Guo F and Yan Y: MicroRNA-133a inhibits the malignant behavior of glioma via downregulation of matrix metallopeptidase 9. Mol Med Rep 13: 3220-3226, 2016
APA
Wang, J., Li, J., Guo, F., & Yan, Y. (2016). MicroRNA-133a inhibits the malignant behavior of glioma via downregulation of matrix metallopeptidase 9. Molecular Medicine Reports, 13, 3220-3226. https://doi.org/10.3892/mmr.2016.4907
MLA
Wang, J., Li, J., Guo, F., Yan, Y."MicroRNA-133a inhibits the malignant behavior of glioma via downregulation of matrix metallopeptidase 9". Molecular Medicine Reports 13.4 (2016): 3220-3226.
Chicago
Wang, J., Li, J., Guo, F., Yan, Y."MicroRNA-133a inhibits the malignant behavior of glioma via downregulation of matrix metallopeptidase 9". Molecular Medicine Reports 13, no. 4 (2016): 3220-3226. https://doi.org/10.3892/mmr.2016.4907