Neurogenesis-based epigenetic therapeutics for Alzheimer's disease (Review)

  • Authors:
    • Xueyuan Li
    • Xinjie Bao
    • Renzhi Wang
  • View Affiliations

  • Published online on: June 10, 2016     https://doi.org/10.3892/mmr.2016.5390
  • Pages: 1043-1053
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Abstract

Alzheimer's disease (AD) is a worldwide health problem with multiple pathogenic causes including aging, and genetic and environmental factors. As the interfaces between genes and the environment, epigenetic mechanisms, including DNA methylation, histone modification and microRNAs, are also involved in the pathogenesis of AD. Neurogenesis occurs throughout life in the normal adult brain of mammals. The neurogenic process, consisting of the proliferation, differentiation and maturation of neural stem cells (NSC), is regulated via epigenetic mechanisms by controlling the expression of specific sets of genes. In the pathology of AD, due to impairments in epigenetic mechanisms, the generation of neurons from NSCs is damaged, which exacerbates the loss of neurons and the deficits in learning and memory function associated with AD. Based on neurogenesis, a number of therapeutic strategies have shown capability in promoting neuronal generation to compensate for the neurons lost in AD, thereby improving cognitive function through epigenetic modifications. This provides potential for the treatment of AD by stimulating neurogenesis using epigenetic strategies. The present review discusses the epigenetics of AD and adult neurogenesis, and summarizes the neurogenesis-based epigenetic therapies targeted at AD. Such a review may offer information for the guidance of future developments of therapeutic strategies for AD.
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August-2016
Volume 14 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Li X, Bao X and Wang R: Neurogenesis-based epigenetic therapeutics for Alzheimer's disease (Review). Mol Med Rep 14: 1043-1053, 2016
APA
Li, X., Bao, X., & Wang, R. (2016). Neurogenesis-based epigenetic therapeutics for Alzheimer's disease (Review). Molecular Medicine Reports, 14, 1043-1053. https://doi.org/10.3892/mmr.2016.5390
MLA
Li, X., Bao, X., Wang, R."Neurogenesis-based epigenetic therapeutics for Alzheimer's disease (Review)". Molecular Medicine Reports 14.2 (2016): 1043-1053.
Chicago
Li, X., Bao, X., Wang, R."Neurogenesis-based epigenetic therapeutics for Alzheimer's disease (Review)". Molecular Medicine Reports 14, no. 2 (2016): 1043-1053. https://doi.org/10.3892/mmr.2016.5390