Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs

Ahn,Changhwan; Shin,Da‑Hye; Lee,Dongoh; Kang,Su‑Myung; Seok,Ju‑Hyung; Kang,Hee Young; Jeung,Eui‑Bae

doi:10.3892/mmr.2016.5725

Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs

Authors:
- Changhwan Ahn
- Da‑Hye Shin
- Dongoh Lee
- Su‑Myung Kang
- Ju‑Hyung Seok
- Hee Young Kang
- Eui‑Bae Jeung
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Affiliations: Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea
Published online on: September 6, 2016 https://doi.org/10.3892/mmr.2016.5725
Pages: 3697-3703
Copyright: © Ahn et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Tight junctions are the outermost structures of intercellular junctions and are classified as transmembrane proteins. These factors form selective permeability barriers between cells, act as paracellular transporters and regulate structural and functional polarity of cells. Although tight junctions have been previously studied, comparison of the transcriptional‑translational levels of these molecules in canine organs remains to be investigated. In the present study, organ‑specific expression of the tight junction proteins, claudin, occludin, junction adhesion molecule A and zona occludens 1 was examined in the canine duodenum, lung, liver and kidney. Results of immunohistochemistry analysis demonstrated that the tight junctions were localized in intestinal villi and glands of the duodenum, bronchiolar epithelia and alveolar walls of the lung, endometrium and myometrium of the hepatocytes, and the distal tubules and glomeruli of the kidney. These results suggest that tight junctions are differently expressed in organs, and therefore may be involved in organ‑specific functions to maintain physiological homeostasis.

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