Neurotoxin β‑N‑methylamino‑L‑alanine induces endoplasmic reticulum stress‑mediated neuronal apoptosis

Corrigendum in: /10.3892/mmr.2018.9242

  • Authors:
    • Haiying Shen
    • Kiyoon Kim
    • Yoojung Oh
    • Kyung Sik Yoon
    • Hyung Hwan Baik
    • Sung Soo Kim
    • Joohun Ha
    • Insug Kang
    • Wonchae Choe
  • View Affiliations

  • Published online on: October 5, 2016     https://doi.org/10.3892/mmr.2016.5802
  • Pages: 4873-4880
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Abstract

β-N-methylamino-L-alanine (BMAA) is a neurotoxin that is closely associated with the incidence of amyotrophic lateral sclerosis, Parkinson's disease and Alzheimer's disease. In cultured neuronal cells, BMAA notably induces the upregulation of endoplasmic reticulum (ER) chaperons and activates the unfolded protein response (UPR) receptor pathways of protein kinase RNA‑like endoplasmic reticulum kinase, inositol‑requiring kinase 1 and transcription factor 6. The ER stress‑specific protein CCAAT/‑enhancer‑binding protein homologous protein (CHOP) affords pro‑apoptotic responses that cause mitochondrial damage and caspase activation. BMAA also induces the activation of mitogen‑activated protein kinase member c‑JUN N‑terminal kinase, p38 and extracellular signal‑regulated kinase, which have been suggested to be involved in the signaling pathway of UPR‑mediated apoptosis. Inhibition of ER stress using ER stress antagonist, salubrinal, attenuated the expression of CHOP and alleviated neuronal death. Overexpression of heat shock protein 70 suppressed the activation of UPR receptors and UPR‑evoked apoptotic signaling. The present findings demonstrated that ER stress induced by BMAA is the important mediator of neuronal injury and apoptotic death, and suggests development in novel therapeutic strategies for treatment.

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Copy and paste a formatted citation
APA
Shen, H., Kim, K., Oh, Y., Yoon, K.S., Baik, H.H., Kim, S.S. ... Choe, W. (2016). Neurotoxin β‑N‑methylamino‑L‑alanine induces endoplasmic reticulum stress‑mediated neuronal apoptosis Corrigendum in /10.3892/mmr.2018.9242. Molecular Medicine Reports, 14, 4873-4880. https://doi.org/10.3892/mmr.2016.5802
MLA
Shen, H., Kim, K., Oh, Y., Yoon, K. S., Baik, H. H., Kim, S. S., Ha, J., Kang, I., Choe, W."Neurotoxin β‑N‑methylamino‑L‑alanine induces endoplasmic reticulum stress‑mediated neuronal apoptosis Corrigendum in /10.3892/mmr.2018.9242". Molecular Medicine Reports 14.5 (2016): 4873-4880.
Chicago
Shen, H., Kim, K., Oh, Y., Yoon, K. S., Baik, H. H., Kim, S. S., Ha, J., Kang, I., Choe, W."Neurotoxin β‑N‑methylamino‑L‑alanine induces endoplasmic reticulum stress‑mediated neuronal apoptosis Corrigendum in /10.3892/mmr.2018.9242". Molecular Medicine Reports 14, no. 5 (2016): 4873-4880. https://doi.org/10.3892/mmr.2016.5802