Effect of zinc deficiency on mouse renal interstitial fibrosis in diabetic nephropathy

  • Authors:
    • Xiuli Zhang
    • Dan Liang
    • Xu Lian
    • Zhi‑Hong Chi
    • Xuemei Wang
    • Yue Zhao
    • Zhang Ping
  • View Affiliations

  • Published online on: October 20, 2016     https://doi.org/10.3892/mmr.2016.5870
  • Pages: 5245-5252
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

There is emerging evidence that tubulointerstitial fibrosis is the final common pathway of the majority of chronic progressive renal diseases, including diabetic nephropathy (DN). Zinc, an essential dietary element, has been suggested to be important for a number of protein functions during fibrosis in vivo and in vitro. However, the effect of zinc deficiency (ZnD) on renal interstitial fibrosis in DN remains unclear. The present study investigated the effect and the underlying mechanisms of ZnD on renal interstitial fibrosis during DN using an streptozotocin‑induced model of diabetes with immunofluorescence staining and western blot analysis. The present study identified that dietary zinc restriction significantly decreased zinc concentrations in the plasma and mouse kidney. ZnD enhanced albuminuria and extracellular matrix protein expression, associated with diabetic renal interstitial fibrosis by activation of renal interstitial fibroblasts and regulation of the expression of fibrosis‑associated factors, which may be mediated by the activation of fibroblasts via the TGF‑β/Smad signaling pathway. The data indicates that ZnD serves an important role in the pathogenic mechanisms of renal interstitial fibrosis during the development of DN.
View Figures
View References

Related Articles

Journal Cover

December-2016
Volume 14 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Liang D, Lian X, Chi ZH, Wang X, Zhao Y and Ping Z: Effect of zinc deficiency on mouse renal interstitial fibrosis in diabetic nephropathy. Mol Med Rep 14: 5245-5252, 2016
APA
Zhang, X., Liang, D., Lian, X., Chi, Z., Wang, X., Zhao, Y., & Ping, Z. (2016). Effect of zinc deficiency on mouse renal interstitial fibrosis in diabetic nephropathy. Molecular Medicine Reports, 14, 5245-5252. https://doi.org/10.3892/mmr.2016.5870
MLA
Zhang, X., Liang, D., Lian, X., Chi, Z., Wang, X., Zhao, Y., Ping, Z."Effect of zinc deficiency on mouse renal interstitial fibrosis in diabetic nephropathy". Molecular Medicine Reports 14.6 (2016): 5245-5252.
Chicago
Zhang, X., Liang, D., Lian, X., Chi, Z., Wang, X., Zhao, Y., Ping, Z."Effect of zinc deficiency on mouse renal interstitial fibrosis in diabetic nephropathy". Molecular Medicine Reports 14, no. 6 (2016): 5245-5252. https://doi.org/10.3892/mmr.2016.5870