Open Access

TRIM37 promotes epithelial‑mesenchymal transition in colorectal cancer

  • Authors:
    • Cheng‑En Hu
    • Jun Gan
  • View Affiliations

  • Published online on: January 16, 2017     https://doi.org/10.3892/mmr.2017.6125
  • Pages: 1057-1062
  • Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

There is substantial research on the oncogenic role of tripartite motif containing 37 (TRIM37); however, its importance in colorectal cancer (CRC) remains to be elucidated. The present study used reverse transcription‑quantitative polymerase chain reaction, immunohistochemistry and western blotting to detect the expression level of TRIM37 in CRC. The importance of TRIM37 in cell proliferation, invasion and metastasis of CRC were investigated through overexpressing or knocking‑down of TRIM37 in CRC cell lines, to observe its function. The present study revealed that TRIM37 was overexpressed in human CRC tissues. High TRIM37 expression resulted in increased CRC proliferation, migration and invasion. Mechanistically, it was confirmed that TRIM37 enhanced invasion and metastasis of CRC via the epithelial‑mesenchymal transition pathway. In conclusion, the present study suggested that TRIM3 may contribute to CRC and act as a potential therapeutic target for CRC treatment.
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March-2017
Volume 15 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Hu CE and Hu CE: TRIM37 promotes epithelial‑mesenchymal transition in colorectal cancer. Mol Med Rep 15: 1057-1062, 2017
APA
Hu, C., & Hu, C. (2017). TRIM37 promotes epithelial‑mesenchymal transition in colorectal cancer. Molecular Medicine Reports, 15, 1057-1062. https://doi.org/10.3892/mmr.2017.6125
MLA
Hu, C., Gan, J."TRIM37 promotes epithelial‑mesenchymal transition in colorectal cancer". Molecular Medicine Reports 15.3 (2017): 1057-1062.
Chicago
Hu, C., Gan, J."TRIM37 promotes epithelial‑mesenchymal transition in colorectal cancer". Molecular Medicine Reports 15, no. 3 (2017): 1057-1062. https://doi.org/10.3892/mmr.2017.6125