Open Access

Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction

  • Authors:
    • Tran Duong Thuy
    • Nam Nhut Phan
    • Chih-Yang Wang
    • Han-Gang Yu
    • Shu-Yin Wang
    • Pung-Ling Huang
    • Yi-Yin Do
    • Yen-Chang Lin
  • View Affiliations

  • Published online on: March 30, 2017     https://doi.org/10.3892/mmr.2017.6420
  • Pages: 2949-2956
  • Copyright: © Thuy et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Diabetes is a risk factor that increases the occurrence and severity of cardiovascular events. Cardiovascular complications are the leading cause of mortality of 75% of patients with diabetes >40 years old. Sesamin, the bioactive compound extracted from Sesamum indicum, is a natural compound that has diverse beneficial effects on hypoglycemia and reducing cholesterol. The aim of this study is to investigate sesamin effects to diabetes-inducing cardiac hypertrophy. In the present study bioinformatics analysis demonstrated cardiac hypertrophy signaling may be the most important pathway for upregulating genes in sesamin-treated groups. To verify the bioinformatics prediction, sesamin was used as the main bioactive compound to attenuate the impact of diabetes induced by streptozotocin (STZ) on cardiac function in a rat model. The results revealed that oral administration of sesamin for 4 weeks (100 and 200 mg/kg body weight) marginally improved blood glucose levels, body weight and significantly ameliorated the effects on heart rate and blood pressure in rats with type 1 diabetes relative to control rats. The QT interval of sesamin was also reduced relative to the control group. The findings indicated that sesamin has potential cardioprotective effects in the STZ-induced diabetes model. This suggested that this can be used as a novel treatment for patients with diabetes with cardiac dysfunction complication.
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May-2017
Volume 15 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Thuy TD, Phan NN, Wang C, Yu H, Wang S, Huang P, Do Y and Lin Y: Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction. Mol Med Rep 15: 2949-2956, 2017
APA
Thuy, T.D., Phan, N.N., Wang, C., Yu, H., Wang, S., Huang, P. ... Lin, Y. (2017). Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction. Molecular Medicine Reports, 15, 2949-2956. https://doi.org/10.3892/mmr.2017.6420
MLA
Thuy, T. D., Phan, N. N., Wang, C., Yu, H., Wang, S., Huang, P., Do, Y., Lin, Y."Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction". Molecular Medicine Reports 15.5 (2017): 2949-2956.
Chicago
Thuy, T. D., Phan, N. N., Wang, C., Yu, H., Wang, S., Huang, P., Do, Y., Lin, Y."Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction". Molecular Medicine Reports 15, no. 5 (2017): 2949-2956. https://doi.org/10.3892/mmr.2017.6420