Transition and heavy metals compared to oxidative parameter balance in patients with deep vein thrombosis: A case-control study

  • Authors:
    • Margherita Ferrante
    • Maria Fiore
    • Gea Oliveri Conti
    • Valerio Fiore
    • Alfina Grasso
    • Chiara Copat
    • Salvatore Santo Signorelli
  • View Affiliations

  • Published online on: March 24, 2017     https://doi.org/10.3892/mmr.2017.6394
  • Pages: 3438-3444
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Our study compared copper (Cu), zinc (Zn) and manganese (Mn), crucial for human normal physio­logy maintenance, and lead (Pb) levels as environmental pollutant, in subjects suffering of deep vein thrombosis of lower limbs (DVTs) vs. healthy subjects. Furthermore, we evaluated oxidative stress parameters, the thiobarbituric acid reactive substances (TBARS) as the sum of malondialdehyde or 1,1,3,3-tetraethoxypropane (MDA) and 4-hydroxynonenal 4-HNE) and cytosolic superoxide dismutase (Cu/Zn-SOD) concentrations in both groups. We recruited 24 DVT cases and 46 healthy subjects as controls. Questionnaire with socio‑demographic, habits and lifestyle were collected. Hair concentrations of Zn, Mn, Cu and Pb were measured by ICP-MS, plasma concentrations of MDA and 4-HNE were measured by HPLC and SOD plasma concentrations were detected by ELISA test. A quantitative and qualitative variables comparison between cases and controls group was made by Mann-Whitney U test and Pearson's Chi-square test, respectively. We found low concentrations of Zn, Mn and Cu vs. high Pb concentrations in DVTs subjects. TBARS were found higher in the cases group, conversely, SOD concentrations were found lower in cases with respect to controls. Furthermore, we found the diet of pathological subjects significantly deficient in vegetables. These results are indicative of a lower enzymatic activity in patients, related to low transition metal levels in the DVTs and high levels of Pb, coupled with an unbalanced diet.
View Figures
View References

Related Articles

Journal Cover

May-2017
Volume 15 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ferrante M, Fiore M, Conti GO, Fiore V, Grasso A, Copat C and Signorelli SS: Transition and heavy metals compared to oxidative parameter balance in patients with deep vein thrombosis: A case-control study. Mol Med Rep 15: 3438-3444, 2017
APA
Ferrante, M., Fiore, M., Conti, G.O., Fiore, V., Grasso, A., Copat, C., & Signorelli, S.S. (2017). Transition and heavy metals compared to oxidative parameter balance in patients with deep vein thrombosis: A case-control study. Molecular Medicine Reports, 15, 3438-3444. https://doi.org/10.3892/mmr.2017.6394
MLA
Ferrante, M., Fiore, M., Conti, G. O., Fiore, V., Grasso, A., Copat, C., Signorelli, S. S."Transition and heavy metals compared to oxidative parameter balance in patients with deep vein thrombosis: A case-control study". Molecular Medicine Reports 15.5 (2017): 3438-3444.
Chicago
Ferrante, M., Fiore, M., Conti, G. O., Fiore, V., Grasso, A., Copat, C., Signorelli, S. S."Transition and heavy metals compared to oxidative parameter balance in patients with deep vein thrombosis: A case-control study". Molecular Medicine Reports 15, no. 5 (2017): 3438-3444. https://doi.org/10.3892/mmr.2017.6394