Effect of continuous positive airway pressure therapy on inflammatory cytokines and atherosclerosis in patients with obstructive sleep apnea syndrome

Jin,Fa; Liu,Jiannan; Zhang,Xiuwei; Cai,Wei; Zhang,Yuqiong; Zhang,Wei; Yang,Jian; Lu,Gan; Zhang,Xilong

doi:10.3892/mmr.2017.7399

Effect of continuous positive airway pressure therapy on inflammatory cytokines and atherosclerosis in patients with obstructive sleep apnea syndrome

Authors:
- Fa Jin
- Jiannan Liu
- Xiuwei Zhang
- Wei Cai
- Yuqiong Zhang
- Wei Zhang
- Jian Yang
- Gan Lu
- Xilong Zhang
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Affiliations: Department of Respiration, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu 211100, P.R. China, Department of Respiratory, Jiangsu Province Official Hospital, Nanjing, Jiangsu 211100, P.R. China, Department of Cardiology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu 211100, P.R. China, Department of Respiratory, Jiangsu Province Hospital, Nanjing, Jiangsu 210029, P.R. China
Published online on: August 30, 2017 https://doi.org/10.3892/mmr.2017.7399
Pages: 6334-6339

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Abstract

Obstructive sleep apnea syndrome (OSAS) is known to be a risk factor for atherosclerosis (AS), derived from a series of chronic inflammatory reactions caused by hypoxia. However, the association between chronic inflammation and high blood pressure caused by hypoxia remains to be fully elucidated. The aim of the present study was to investigate the effect of continuous positive airway pressure (CPAP) therapy on inflammatory cytokines and AS. A total of 100 patients with OSAS and 50 healthy control subjects were enrolled. Fresh venous blood samples were collected prior to and following a 3‑months period of CPAP treatment. The inflammatory factors, interleukin (IL)‑18 and tumor necrosis factor (TNF)‑α, C‑reactive protein (CRP), intercellular cell adhesion molecule 1 (ICAM‑1), vascular cell adhesion molecule 1 (VCAM‑1), E‑selectin and P‑selectin, were detected using standard enzyme‑linked immunosorbent assay kits. Intima‑media thickness (IMT), brachial‑ankle pulse wave velocity (Ba‑PWV), apnea‑hypopnea index (AHI) and transcutaneous oxygen saturation (SpO2) were also detected to compare differences prior to and following treatment. The results showed that, compared with the pre‑treatment data, the expression levels of IL‑8, TNF‑α, CRP, ICAM‑1, VCAM‑1, E‑selectin and P‑selectin were significantly decreased following treatment (P<0.05). The AHI, IMT, blood pressure and Ba‑PWV values were significantly decreased (P<0.05), and the SpO2 was increased (P<0.05). Taken together, by comparing the pre‑ and post‑intervention data, it was confirmed that inflammatory factors were involved in the process of AS in patients with OSAS. Following CPAP treatment, blood pressure and primary indicators in the patients improved.

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